Life at new extremes: Integrating stress physiology and the bio-exposome in the Anthropocene

Abstract

Conventional physiological research has focused on elucidating the endogenous mechanisms that underly the adaptations of species to life in extreme habitats, such as polar regions or deserts. In this review article, we argue that even habitats that are not considered extremes are facing unpredictable, rapid, and strong modifications due to human activities that expose animals to novel extreme conditions. Thus, physiological research on these animals can offer insight on the role of physiological plasticity in driving their resilience and adaptation. To this end, we discuss how stress physiology (with a particular focus on oxidative stress) has a central role in mediating the interaction between the exposome (measure of all the environmental exposures of an individual in a lifetime) and cellular processes (bio-exposome) in the contexts of relevant extreme anthropogenic changes to the habitat conditions. We also provide concrete examples on the relationship between oxidative stress and the bio-exposome in free-living animals, and how this research can be relevant to human health. Finally, we propose future research directions integrating the bio-exposome and the One Health framework to achieve a holistic understanding of the proximate mechanisms underlying individual responses to extreme anthropogenic environmental changes.