Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/51951
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dc.contributor.authorSchartl, Manfredit
dc.contributor.authorWoltering, Joost Mit
dc.contributor.authorIrisarri, Ikerit
dc.contributor.authorDu, Kangit
dc.contributor.authorKneitz, Susanneit
dc.contributor.authorPippel, Martinit
dc.contributor.authorBrown, Thomasit
dc.contributor.authorFranchini, Paoloit
dc.contributor.authorLi, Jingit
dc.contributor.authorLi, Mingit
dc.contributor.authorAdolfi, Mateusit
dc.contributor.authorWinkler, Sylkeit
dc.contributor.authorde Freitas Sousa, Josaneit
dc.contributor.authorChen, Zhuoxinit
dc.contributor.authorJacinto, Sandrait
dc.contributor.authorKvon, Evgeny Zit
dc.contributor.authorCorrea de Oliveira, Luis Rogérioit
dc.contributor.authorMonteiro, Erikait
dc.contributor.authorBaia Amaral, Danielsonit
dc.contributor.authorBurmester, Thorstenit
dc.contributor.authorChalopin, Domitilleit
dc.contributor.authorSuh, Alexanderit
dc.contributor.authorMyers, Eugeneit
dc.contributor.authorSimakov, Olegit
dc.contributor.authorSchneider, Igorit
dc.contributor.authorMeyer, Axelit
dc.date.accessioned2024-10-30T13:16:38Z-
dc.date.available2024-10-30T13:16:38Z-
dc.date.issued2024it
dc.identifier.issn0028-0836it
dc.identifier.urihttp://hdl.handle.net/2067/51951-
dc.description.abstractThe genomes of living lungfishes can inform on the molecular-developmental basis of the Devonian sarcopterygian fish-tetrapod transition. We de novo sequenced the genomes of the African (Protopterus annectens) and South American lungfishes (Lepidosiren paradoxa). The Lepidosiren genome (about 91 Gb, roughly 30 times the human genome) is the largest animal genome sequenced so far and more than twice the size of the Australian (Neoceratodus forsteri)1 and African2 lungfishes owing to enlarged intergenic regions and introns with high repeat content (about 90%). All lungfish genomes continue to expand as some transposable elements (TEs) are still active today. In particular, Lepidosiren's genome grew extremely fast during the past 100 million years (Myr), adding the equivalent of one human genome every 10 Myr. This massive genome expansion seems to be related to a reduction of PIWI-interacting RNAs and C2H2 zinc-finger and Krüppel-associated box (KRAB)-domain protein genes that suppress TE expansions. Although TE abundance facilitates chromosomal rearrangements, lungfish chromosomes still conservatively reflect the ur-tetrapod karyotype. Neoceratodus' limb-like fins still resemble those of their extinct relatives and remained phenotypically static for about 100 Myr. We show that the secondary loss of limb-like appendages in the Lepidosiren-Protopterus ancestor was probably due to loss of sonic hedgehog limb-specific enhancers.it
dc.rightsAttribution-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/*
dc.titleThe genomes of all lungfish inform on genome expansion and tetrapod evolutionit
dc.typearticle*
dc.identifier.doi10.1038/s41586-024-07830-1it
dc.identifier.pmid39143221it
dc.relation.journalNATUREit
dc.relation.firstpage96it
dc.relation.lastpage103it
dc.relation.volume634it
dc.relation.issue8032it
dc.description.internationalit
dc.type.miur262*
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.grantfulltextrestricted-
item.openairetypearticle-
crisitem.journal.journalissn0028-0836-
crisitem.journal.anceE116312-
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