Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/51850
Title: Synthesis of Benzoxazines by Heterogeneous Multicomponent Biochemo Multienzymes Cascade Reaction
Authors: Tomaino, Elisabetta
Capecchi, Eliana 
Ubertini, Valentina
Piccinino, Davide
Bizzarri, Bruno M
Saladino, Raffaele 
Journal: Journal of Organic Chemistry 
Issue Date: 2024
Abstract: 
This work describes the possibility to combine multicomponent chemistry and multienzymes cascade transformations in a unique reactive framework to yield highly functionalized 1,4-benzoxazines under favorable heterogeneous conditions. The synthetic scheme involved the generation in situ of electrophilic reactive quinone intermediates of tyrosol esters catalyzed by lipase M and tyrosinase followed by nucleophilic 1,6-Michael addition of selected α-amino acid methyl esters, and successive intramolecular lactonization and aromatization processes. The immobilization of the multienzymes cascade on electroactive lignin nanoparticles improved the sustainability and recyclability of the overall system.
URI: http://hdl.handle.net/2067/51850
ISSN: 1434-193X
DOI: 10.1021/acs.joc.3c02314
Appears in Collections:A1. Articolo in rivista

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