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Title: Basophil Activation Test in the Diagnosis of Anisakis Allergy: An Observational Study from an Area of High Seafood Consumption in Italy
Authors: Brusca, Ignazio
Barrale, Maria
Zarcone, Maurizio
Fruscione, Santo
Onida, Rosa
De Bella, Daniele Domenico
Alba, Davide
Belluzzo, Miriam
Uasuf, Carina Gabriela
Cammilleri, Gaetano
Costa, Antonella
Ferrantelli, Vincenzo
Savatteri, Alessandra
Cannizzaro, Emanuele
Calamusa, Giuseppe
Lacca, Guido
Maida, Carmelo Massimo
Pipitone, Salvatore
D'Atria, Alida
Palomba, Marialetizia 
Costantino, Claudio
Mattiucci, Simonetta
Mazzucco, Walter
Issue Date: 2023
The rising popularity of undercooked or raw seafood containing larvae of the Anisakis parasite has led to issues of public health concern due to allergic manifestations. We conducted an observational study on the use of an innovative Anisakis allergy diagnostic algorithm in a convenience sample of 53 allergic outpatients recruited in Western Sicily, between April 2021 and March 2022. We included individuals with an anamnesis suggestive of IgE sensitization to Anisakis reporting clinical manifestation in the last month due to allergic reactions after eating fresh fish, or in subjects at high exposure risk with sea products while abstaining from fish ingestion, excluding those with documented fish sensitization. Outpatients were tested via Skin Prick Test, IgE-specific dosage and Basophil Activation Test (BAT). Twenty-six outpatients were diagnosed with Anisakis, while 27 with Chronic Urticaria (CU). We found a seven-fold excess risk for Anisakis (p4) positivity in the Anisakis allergic outpatients, as compared to the CU ones. BAT showed the best diagnostic accuracy (92.45%) and specificity (100%), while specific IgE to Ascaris (p1) documented the best sensitivity (92.31%) but a very low specificity (37.04%). In conclusion, our findings may represent a potentially useful contribution to the future development of updated clinical guidelines.
ISSN: 2076-0817
DOI: 10.3390/pathogens12060777
Rights: Attribution-NoDerivatives 4.0 International
Appears in Collections:A1. Articolo in rivista

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