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Title: Equus caballus Papillomavirus Type-9 (EcPV9): First Detection in Asymptomatic Italian Horses
Authors: De Paolis, Livia
De Ciucis, Chiara Grazia
Peletto, Simone
Cappelli, Katia
Mecocci, Samanta
Nervo, Tiziana
Guardone, Lisa
Crescio, Maria Ines
Pietrucci, Daniele 
Fruscione, Floriana
Gabbianelli, Federica
Turco, Silvia 
Varello, Katia
Donato, Gian Guido
Maurella, Cristiana
Modesto, Paola
Maniaci, Maria Grazia
Chillemi, Giovanni 
Ghelardi, Alessandro
Razzuoli, Elisabetta
Journal: VIRUSES 
Issue Date: 2022
Papillomavirus (PV) infections may be related to anogenital lesions and cancer development in humans and several other animal species. To date, 11 different PVs have been reported in horses. Among them, a newly described PV named Equus caballus Papillomavirus Type9 (EcPV9) was thus far only reported in the semen of a stallion with penile lesions in Australia. This study reports for the first time the presence of EcPV9 in asymptomatic Italian horses. From July 2020 to January 2022, genital brush samples were collected from 209 horses with no apparent signs of neoplastic disease and no PV-associated lesions, clinically examined at the Didactic Veterinary University Hospital (OVUD) of Perugia and at the Veterinary University Hospital (OVU) of Turin. Brushes were submitted to real-time PCR targeting the EcPV9-L1 region. The first amplification targeted a region of ~116 bp, followed by the amplification and sequencing of ~533 bp of the positive samples. EcPV9-L1 DNA was found in eleven horses (5.3%), all female and mainly English Thoroughbred. Co-infection with EcPV2-L1 was found in 7 out of the 11 EcPV9-L1 positive horses (63.6%). This study contributes to the description of the prevalence of exposure or infection of EcPVs in the horse population in Italy, for which data are still limited. In this regard, here we provide a phylogenetic analysis and the completely reconstructed viral genomes of two Italian EcPV type 9 isolates, as well as four EcPV type 2 obtained from co-infected animals.
ISSN: 1999-4915
DOI: 10.3390/v14092050
Rights: CC0 1.0 Universal
Appears in Collections:A1. Articolo in rivista

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