Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/51156
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dc.contributor.authorRomeo, Isabellait
dc.contributor.authorPrandi, Ingrid Guarnettiit
dc.contributor.authorGiombini, Emanuelait
dc.contributor.authorGruber, Cesare Ernesto Mariait
dc.contributor.authorPietrucci, Danieleit
dc.contributor.authorBorocci, Stefanoit
dc.contributor.authorAbid, Nabilit
dc.contributor.authorFava, Annait
dc.contributor.authorBeccari, Andrea Rit
dc.contributor.authorChillemi, Giovanniit
dc.contributor.authorTalarico, Carmineit
dc.date.accessioned2024-02-29T23:01:25Z-
dc.date.available2024-02-29T23:01:25Z-
dc.date.issued2022it
dc.identifier.issn1661-6596it
dc.identifier.urihttp://hdl.handle.net/2067/51156-
dc.description.abstractA large number of SARS-CoV-2 mutations in a short period of time has driven scientific research related to vaccines, new drugs, and antibodies to combat the new variants of the virus. Herein, we present a web portal containing the structural information, the tridimensional coordinates, and the molecular dynamics trajectories of the SARS-CoV-2 spike protein and its main variants. The Spike Mutants website can serve as a rapid online tool for investigating the impact of novel mutations on virus fitness. Taking into account the high variability of SARS-CoV-2, this application can help the scientific community when prioritizing molecules for experimental assays, thus, accelerating the identification of promising drug candidates for COVID-19 treatment. Below we describe the main features of the platform and illustrate the possible applications for speeding up the drug discovery process and hypothesize new effective strategies to overcome the recurrent mutations in SARS-CoV-2 genome.it
dc.rightsCC0 1.0 Universal*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.titleThe Spike Mutants Website: A Worldwide Used Resource against SARS-CoV-2it
dc.typearticle*
dc.identifier.doi10.3390/ijms232113082it
dc.identifier.pmid36361870it
dc.identifier.urlhttps://dspace.unitus.it/handle/2067/48540it
dc.relation.journalINTERNATIONAL JOURNAL OF MOLECULAR SCIENCESit
dc.relation.firstpage13082it
dc.relation.volume23it
dc.relation.issue21it
dc.type.miur262*
item.openairetypearticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextrestricted-
item.fulltextWith Fulltext-
crisitem.journal.journalissn1661-6596-
crisitem.journal.anceE217024-
Appears in Collections:A1. Articolo in rivista
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