Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/51154
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dc.contributor.authorTurco, Silviait
dc.contributor.authorRusso, Simoneit
dc.contributor.authorPietrucci, Danieleit
dc.contributor.authorFilippi, Anitait
dc.contributor.authorMilanesi, Marcoit
dc.contributor.authorLuzzago, Camillait
dc.contributor.authorGarbarino, Chiarait
dc.contributor.authorPalladini, Giorgiait
dc.contributor.authorChillemi, Giovanniit
dc.contributor.authorRicchi, Matteoit
dc.date.accessioned2024-02-29T22:57:52Z-
dc.date.available2024-02-29T22:57:52Z-
dc.date.issued2024it
dc.identifier.issn2297-1769it
dc.identifier.urihttp://hdl.handle.net/2067/51154-
dc.description.abstractMycobacterium avium subsp. paratuberculosis (MAP) is the aetiological agent of paratuberculosis (Johne's disease) in both domestic and wild ruminants. In the present study, using a whole-genome sequence (WGS) approach, we investigated the genetic diversity of 15 Mycobacterium avium field strains isolated in the last 10 years from red deer inhabiting the Stelvio National Park and affected by paratuberculosis. Combining de novo assembly and a reference-based method, followed by a pangenome analysis, we highlight a very close relationship among 13 MAP field isolates, suggesting that a single infecting event occurred in this population. Moreover, two isolates have been classified as Mycobacterium avium subsp. hominissuis, distinct from the other MAPs under comparison but close to each other. This is the first time that this subspecies has been found in Italy in samples without evident epidemiological correlations, having been isolated in two different locations of the Stelvio National Park and in different years. Our study highlights the importance of a multidisciplinary approach incorporating molecular epidemiology and ecology into traditional infectious disease knowledge in order to investigate the nature of infectious disease in wildlife populations.it
dc.rightsCC0 1.0 Universal*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.titleHigh clonality of Mycobacterium avium subsp. paratuberculosis field isolates from red deer revealed by two different methodological approaches of comparative genomic analysisit
dc.typearticle*
dc.identifier.doi10.3389/fvets.2024.1301667it
dc.identifier.pmid38379925it
dc.identifier.urlhttps://dspace.unitus.it/handle/2067/50726it
dc.relation.journalFRONTIERS IN VETERINARY SCIENCEit
dc.relation.firstpage1301667it
dc.relation.volume11it
dc.type.miur262*
item.openairetypearticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextrestricted-
item.fulltextWith Fulltext-
crisitem.journal.journalissn2297-1769-
crisitem.journal.anceE232653-
Appears in Collections:A1. Articolo in rivista
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