Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/51151
Title: Not just a Snapshot: An Italian Longitudinal Evaluation of Stability of Gut Microbiota Findings in Parkinson's Disease
Authors: Cerroni, Rocco
Pietrucci, Daniele 
Teofani, Adelaide
Chillemi, Giovanni 
Liguori, Claudio
Pierantozzi, Mariangela
Unida, Valeria
Selmani, Sidorela
Mercuri, Nicola Biagio
Stefani, Alessandro
Journal: BRAIN SCIENCES 
Issue Date: 2022
Abstract: 
Most research analyzed gut-microbiota alterations in Parkinson's disease (PD) through cross-sectional studies, as single snapshots, without considering the time factor to either confirm methods and findings or observe longitudinal variations. In this study, we introduce the time factor by comparing gut-microbiota composition in 18 PD patients and 13 healthy controls (HC) at baseline and at least 1 year later, also considering PD clinical features. PD patients and HC underwent a fecal sampling at baseline and at a follow-up appointment. Fecal samples underwent sequencing and 16S rRNA amplicons analysis. Patients'clinical features were valued through Hoehn&Yahr (H&Y) staging-scale and Movement Disorder Society Unified PD Rating Scale (MDS-UPDRS) Part-III. Results demonstrated stability in microbiota findings in both PD patients and HC over a period of 14 months: both alfa and beta diversity were maintained in PD patients and HC over the observation period. In addition, differences in microbiota composition between PD patients and HC remained stable over the time period. Moreover, during the same period, patients did not experience any worsening of either staging or motor impairment. Our findings, highlighting the stability and reproducibility of the method, correlate clinical and microbiota stability over time and open the scenario to more extensive longitudinal evaluations.
URI: http://hdl.handle.net/2067/51151
ISSN: 2076-3425
DOI: 10.3390/brainsci12060739
Rights: CC0 1.0 Universal
Appears in Collections:A1. Articolo in rivista

Files in This Item:
File Description SizeFormat Existing users please
2022_05_BrainSciences_Cerroni.pdf1.43 MBAdobe PDF    Request a copy
Show full item record

SCOPUSTM   
Citations

7
Last Week
0
Last month
checked on May 19, 2024

Page view(s)

3
checked on May 25, 2024

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons