Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/51042
DC FieldValueLanguage
dc.contributor.authorImperlini, Estherit
dc.contributor.authorCorbo, Claudiait
dc.date.accessioned2024-02-27T21:34:45Z-
dc.date.available2024-02-27T21:34:45Z-
dc.date.issued2023it
dc.identifier.issn0006-291Xit
dc.identifier.urihttp://hdl.handle.net/2067/51042-
dc.description.abstractIn cancer research today, one of the major challenges is the eradication of cancer stem cells (CSCs) within the tumor mass. These cells play a crucial role in initiating, growing, and maintaining the tumor. Evidence has demonstrated the presence and significance of CSCs in the development and progression of osteosarcoma (OS). However, our understanding of the specific markers for OS stem cells remains limited. In this study, we aim to identify distinct biomarkers for this cell population by conducting a proteomic analysis comparing OS stem cells to their non-stem counterparts. Our investigation focuses on a particular cell line called 3AB-OS, which exhibits stem-like characteristics, and its differentiated parental cell line, MG63. Through this research, we discovered 63 proteins exclusively expressed in 3AB-OS cells. Applying an in silico bioinformatics approach, we determined that the majority of these proteins are associated with RNA metabolism. Additionally, we identified a potential correlation between the insulin-like growth factor-binding proteins (IGF2BPs) signaling pathway and the tumorigenic and stemness features observed in 3AB-OS cells.it
dc.language.isoengit
dc.titleUnveiling the protein signature of the human osteosarcoma 3AB-OS cancer stem cell lineit
dc.typearticle*
dc.identifier.doi10.1016/j.bbrc.2023.07.012it
dc.identifier.pmid37481941it
dc.identifier.scopus2-s2.0-85165654125it
dc.relation.journalBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONSit
dc.relation.firstpage36it
dc.relation.lastpage41it
dc.relation.volume676it
dc.description.internationalnoit
dc.contributor.countryITAit
dc.type.miur262*
item.openairetypearticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextrestricted-
item.languageiso639-1en-
item.fulltextWith Fulltext-
crisitem.journal.journalissn0006-291X-
crisitem.journal.anceE022039-
Appears in Collections:A1. Articolo in rivista
Files in This Item:
File Description SizeFormat Existing users please
1-s2.0-S0006291X23008604-main.pdf2.18 MBAdobe PDF    Request a copy
Show simple item record

Page view(s)

5
checked on May 29, 2024

Download(s)

1
checked on May 29, 2024

Google ScholarTM

Check

Altmetric


All documents in the "Unitus Open Access" community are published as open access.
All documents in the community "Prodotti della Ricerca" are restricted access unless otherwise indicated for specific documents