Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/51042
Title: Unveiling the protein signature of the human osteosarcoma 3AB-OS cancer stem cell line
Authors: Imperlini, Esther 
Corbo, Claudia
Journal: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 
Issue Date: 2023
Abstract: 
In cancer research today, one of the major challenges is the eradication of cancer stem cells (CSCs) within the tumor mass. These cells play a crucial role in initiating, growing, and maintaining the tumor. Evidence has demonstrated the presence and significance of CSCs in the development and progression of osteosarcoma (OS). However, our understanding of the specific markers for OS stem cells remains limited. In this study, we aim to identify distinct biomarkers for this cell population by conducting a proteomic analysis comparing OS stem cells to their non-stem counterparts. Our investigation focuses on a particular cell line called 3AB-OS, which exhibits stem-like characteristics, and its differentiated parental cell line, MG63. Through this research, we discovered 63 proteins exclusively expressed in 3AB-OS cells. Applying an in silico bioinformatics approach, we determined that the majority of these proteins are associated with RNA metabolism. Additionally, we identified a potential correlation between the insulin-like growth factor-binding proteins (IGF2BPs) signaling pathway and the tumorigenic and stemness features observed in 3AB-OS cells.
URI: http://hdl.handle.net/2067/51042
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2023.07.012
Appears in Collections:A1. Articolo in rivista

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