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Title: Amino Acid Metabolism in Leukocytes Showing In Vitro IgG Memory from SARS-CoV2-Infected Patients
Authors: Fanelli Giuseppina
Lelli Veronica
Rinalducci Sara
Timperio, Annamaria 
Journal: DISEASES 
Issue Date: 2024
The immune response to infectious diseases is directly influenced by metabolic activities.
COVID-19 is a disease that affects the entire body and can significantly impact cellular metabolism.
Recent studies have focused their analysis on the potential connections between post-infection stages
of SARS-CoV2 and different metabolic pathways. The spike S1 antigen was found to have in vitro
IgG antibody memory for PBMCs when obtaining PBMC cultures 60–90 days post infection, and
a significant increase in S-adenosyl homocysteine, sarcosine, and arginine was detected by mass
spectrometric analysis. The involvement of these metabolites in physiological recovery from viral
infections and immune activity is well documented, and they may provide a new and simple method
to better comprehend the impact of SARS-CoV2 on leukocytes. Moreover, there was a significant
change in the metabolism of the tryptophan and urea cycle pathways in leukocytes with IgG memory.
With these data, together with results from the literature, it seems that leukocyte metabolism is
reprogrammed after viral pathogenesis by activating
ISSN: 2079-9721
Rights: Attribution 4.0 International
Appears in Collections:A1. Articolo in rivista

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