Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/50940
Title: Stereo- and regioselective gold(I)-catalyzed hydroamination of 2-(arylethynyl)pyridines with anilines
Authors: Fochetti, Andrea 
Fabrizi, Giancarlo
Iazzetti, Antonia
Goggiamani, Antonella
Ghirga, Francesca
Cacchi, Sandro
Journal: ORGANIC & BIOMOLECULAR CHEMISTRY 
Issue Date: 2019
Abstract: 
The gold-catalyzed hydroamination of 2-(arylethynyl)pyridines with anilines affords stereoselectively Z-enamine products with excellent regioselectivity. The reaction proceeds with moderate to excellent yields and accommodates a diverse range of functional groups on alkynes (ether, bromo, trifluoromethyl, acetyl, and carbomethoxy) and anilines (ether, bromo, chloro, and carbethoxy). The stereochemistry of the obtained enamines is complementary to that reported in previous studies. A plausible explanation for the observed selectivity was attained by means of NMR experiments.
URI: http://hdl.handle.net/2067/50940
ISSN: 1477-0539
DOI: 10.1039/c8ob02356e
Appears in Collections:A1. Articolo in rivista

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