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http://hdl.handle.net/2067/48965| Title: | A Green Blue LED-Driven Two-Liquid-Phase One-Pot Procedure for the Synthesis of Estrogen-Related Quinol Prodrugs | Authors: | De Marchi, Elisa Botta, Lorenzo Bizzarri, Bruno Mattia Saladino, Raffaele |
Journal: | MOLECULES | Issue Date: | 2022 | Abstract: | Quinol derivatives of estrogens are effective pro-drugs in steroid replacement therapy. Here, we report that these compounds can be synthesized in one-pot conditions and high yield by blue LED-driven photo-oxygenation of parent estrogens. The oxidation was performed in buffer and eco-certified 2-methyltetrahydrofuran as the two-liquid-phase reaction solvent, and in the presence of meso-tetraphenyl porphyrin as the photosensitizer. Two steroidal prodrugs 10β, 17β-dihydroxyestra-1,4-dien-3-one (DHED) and 10β-Hydroxyestra-1,4-diene-3,17-dione (HEDD) were obtained with high yield and selectivity. |
URI: | http://hdl.handle.net/2067/48965 | ISSN: | 1420-3049 | DOI: | 10.3390/molecules27248961 | Rights: | Attribution-NonCommercial-NoDerivatives 4.0 International |
| Appears in Collections: | A1. Articolo in rivista |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| A green blue LED-driven two-liquid- phase One-Pot procedure for the synthesis of Estrogen-related quinol prodrugs.pdf | Article | 871.73 kB | Adobe PDF | View/Open |
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