Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/48599
Title: Apple Polyphenol Diet Extends Lifespan, Slows down Mitotic Rate and Reduces Morphometric Parameters in Drosophila Melanogaster: A Comparison between Three Different Apple Cultivars
Authors: Bongiorni Silvia
Arisi Ivan
Ceccantoni Brunella
Rossi Cristina
Cresta Camilla
Castellani Simona
Forgione Ivano 
Rinalducci Sara 
Muleo Rosario 
Prantera Giorgio 
Journal: ANTIOXIDANTS 
Issue Date: 2022
Abstract: 
Plant-derived polyphenols exhibit beneficial effects on physiological and pathological processes, including cancer and neurodegenerative disorders, mainly because of their antioxidant activity. Apples are highly enriched in these compounds, mainly in their peel. The Tuscia Red (TR) apple variety exhibits the peculiar characteristic of depositing high quantities of polyphenols in the pulp, the edible part of the fruit. Since polyphenols, as any natural product, cannot be considered a panacea per se, in this paper, we propose to assess the biological effects of TR flesh extracts, in comparison with two commercial varieties, in a model system, the insect Drosophila melanogaster, largely recognized as a reliable system to test the in vivo effects of natural and synthetic compounds. We performed a comparative, qualitative and quantitative analysis of the polyphenol compositions of the three cultivars and found that TR flesh shows the highest content of polyphenols, and markedly, anthocyanins. Then, we focused on their effects on a panel of physiological, morphometrical, cellular and behavioral phenotypes in wild-type D. melanogaster. We found that all the apple polyphenol extracts showed dose-dependent effects on most of the phenotypes we considered. Remarkably, all the varieties induced a strong relenting of the cell division rate.
URI: http://hdl.handle.net/2067/48599
ISSN: 2076-3921
DOI: 10.3390/antiox11112086
Rights: Attribution 4.0 International
Appears in Collections:A1. Articolo in rivista

Files in This Item:
File Description SizeFormat Existing users please
Antioxidants 2022_Drosophila Tuscia Red Apple.pdffull paper1.11 MBAdobe PDF    Request a copy
Show full item record

SCOPUSTM   
Citations

3
Last Week
0
Last month
1
checked on Mar 24, 2024

Page view(s)

44
Last Week
0
Last month
2
checked on Mar 27, 2024

Download(s)

1
checked on Mar 27, 2024

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons