Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2067/48599
Titolo: Apple Polyphenol Diet Extends Lifespan, Slows down Mitotic Rate and Reduces Morphometric Parameters in Drosophila Melanogaster: A Comparison between Three Different Apple Cultivars
Autori: Bongiorni Silvia
Arisi Ivan
Ceccantoni Brunella
Rossi Cristina
Cresta Camilla
Castellani Simona
Forgione Ivano 
Rinalducci Sara 
Muleo Rosario 
Prantera Giorgio 
Data pubblicazione: 2022
Plant-derived polyphenols exhibit beneficial effects on physiological and pathological processes, including cancer and neurodegenerative disorders, mainly because of their antioxidant activity. Apples are highly enriched in these compounds, mainly in their peel. The Tuscia Red (TR) apple variety exhibits the peculiar characteristic of depositing high quantities of polyphenols in the pulp, the edible part of the fruit. Since polyphenols, as any natural product, cannot be considered a panacea per se, in this paper, we propose to assess the biological effects of TR flesh extracts, in comparison with two commercial varieties, in a model system, the insect Drosophila melanogaster, largely recognized as a reliable system to test the in vivo effects of natural and synthetic compounds. We performed a comparative, qualitative and quantitative analysis of the polyphenol compositions of the three cultivars and found that TR flesh shows the highest content of polyphenols, and markedly, anthocyanins. Then, we focused on their effects on a panel of physiological, morphometrical, cellular and behavioral phenotypes in wild-type D. melanogaster. We found that all the apple polyphenol extracts showed dose-dependent effects on most of the phenotypes we considered. Remarkably, all the varieties induced a strong relenting of the cell division rate.
URI: http://hdl.handle.net/2067/48599
ISSN: 2076-3921
DOI: 10.3390/antiox11112086
Diritti: Attribution 4.0 International
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