Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2067/48595
Titolo: REDIportal: millions of novel A-to-I RNA editing events from thousands of RNAseq experiments
Autori: Mansi, Luigi
Tangaro, Marco Antonio
Lo Giudice, Claudio
Flati, Tiziano
Kopel, Eli
Schaffer, Amos Avraham
Castrignan√≤, Tiziana 
Chillemi, Giovanni 
Pesole, Graziano
Picardi, Ernesto
Rivista: NUCLEIC ACIDS RESEARCH 
Data pubblicazione: 2021
Abstract: 
RNA editing is a relevant epitranscriptome phenomenon able to increase the transcriptome and proteome diversity of eukaryotic organisms. ADAR mediated RNA editing is widespread in humans in which millions of A-to-I changes modify thousands of primary transcripts. RNA editing has pivotal roles in the regulation of gene expression or modulation of the innate immune response or functioning of several neurotransmitter receptors. Massive transcriptome sequencing has fostered the research in this field. Nonetheless, different aspects of the RNA editing biology are still unknown and need to be elucidated. To support the study of A-to-I RNA editing we have updated our REDIportal catalogue raising its content to about 16 millions of events detected in 9642 human RNAseq samples from the GTEx project by using a dedicated pipeline based on the HPC version of the REDItools software. REDIportal now allows searches at sample level, provides overviews of RNA editing profiles per each RNAseq experiment, implements a Gene View module to look at individual events in their genic context and hosts the CLAIRE database. Starting from this novel version, REDIportal will start collecting non-human RNA editing changes for comparative genomics investigations. The database is freely available at http://srv00.recas.ba.infn.it/atlas/index.html.
URI: http://hdl.handle.net/2067/48595
ISSN: 1362-4962
DOI: 10.1093/nar/gkaa916
Diritti: Attribution-NonCommercial-NoDerivatives 4.0 International
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