Please use this identifier to cite or link to this item:
http://hdl.handle.net/2067/48594| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Gabellone, Sofia | it |
| dc.contributor.author | Piccinino, Davide | it |
| dc.contributor.author | Filippi, Silvia | it |
| dc.contributor.author | Castrignanò, Tiziana | it |
| dc.contributor.author | Zippilli, Claudia | it |
| dc.contributor.author | Del Buono, Davide | it |
| dc.contributor.author | Saladino, Raffaele | it |
| dc.date.accessioned | 2022-11-19T16:31:26Z | - |
| dc.date.available | 2022-11-19T16:31:26Z | - |
| dc.date.issued | 2022 | it |
| dc.identifier.issn | 1422-0067 | it |
| dc.identifier.uri | http://hdl.handle.net/2067/48594 | - |
| dc.description.abstract | We report here the synthesis of novel thymine biomimetic photo-adducts bearing an alkane spacer between nucleobases and characterized by antimelanoma activity against two mutated cancer cell lines overexpressing human Topoisomerase 1 (TOP1), namely SKMEL28 and RPMI7951. Among them, Dewar Valence photo-adducts showed a selectivity index higher than the corresponding pyrimidine-(6-4)-pyrimidone and cyclobutane counterpart and were characterized by the highest affinity towards TOP1/DNA complex as evaluated by molecular docking analysis. The antimelanoma activity of novel photo-adducts was retained after loading into UV photo-protective lignin nanoparticles as stabilizing agent and efficient drug delivery system. Overall, these results support a combined antimelanoma and UV sunscreen strategy involving the use of photo-protective lignin nanoparticles for the controlled release of thymine dimers on the skin followed by their sacrificial transformation into photo-adducts and successive inhibition of melanoma and alert of cellular UV machinery repair pathways. | it |
| dc.format.medium | ELETTRONICO | it |
| dc.language.iso | eng | it |
| dc.rights | Attribution 4.0 International | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
| dc.title | Lignin Nanoparticles Deliver Novel Thymine Biomimetic Photo-Adducts with Antimelanoma Activity | it |
| dc.type | article | * |
| dc.identifier.doi | 10.3390/ijms23020915 | it |
| dc.identifier.url | https://www.mdpi.com/1422-0067/23/2/915 | it |
| dc.relation.journal | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | it |
| dc.relation.article | 915 | it |
| dc.relation.volume | 23 | it |
| dc.relation.issue | 2 | it |
| dc.description.numberofauthors | 7 | it |
| dc.description.international | no | it |
| dc.contributor.country | ITA | it |
| dc.type.miur | 262 | * |
| item.fulltext | With Fulltext | - |
| item.openairetype | article | - |
| item.cerifentitytype | Publications | - |
| item.grantfulltext | restricted | - |
| item.languageiso639-1 | en | - |
| item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
| crisitem.journal.journalissn | 1422-0067 | - |
| crisitem.journal.ance | E184525 | - |
| Appears in Collections: | A1. Articolo in rivista | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| ijms-23-00915 (4).pdf | 3.65 MB | Adobe PDF | View/Open |
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