Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/48325
Title: Transport of cationic liposomes in a human blood brain barrier model: Role of the stereochemistry of the gemini amphiphile on liposome biological features
Authors: Buonocore, Francesco 
Beatrice Simonis
D. Vignone
O. Gonzalez Paz
E. Donati
M.L. Falchetti
C. Bombelli
A. Cellucci
G. Auciello
I. Fini
L. Galantini
R.Z.R. Syeda
M. Mazzonna
M.P. Mongiardi
F. Ceccacci
A. Di Marco
G. Mancini
Journal: JOURNAL OF COLLOID AND INTERFACE SCIENCE 
Issue Date: 2022
Abstract: 
Hypothesis: The positive charge on liposome surface is known to promote the crossing of the Blood brain
barrier (BBB). However, when diastereomeric cationic gemini amphiphiles are among lipid membrane
components, also the stereochemistry may affect the permeability of the vesicle across the BBB.
Experiments: Liposomes featuring cationic diasteromeric gemini amphiphiles were formulated, characterized,
and their interaction with cell culture models of BBB investigated.
URI: http://hdl.handle.net/2067/48325
ISSN: 0021-9797
DOI: https://doi.org/10.1016/j.jcis.2022.07.025
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Appears in Collections:A1. Articolo in rivista

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