Please use this identifier to cite or link to this item:
|Title:||GC-MS investigation and antiproliferative activities of extracts from male and female flowers of Schinus molle L||Authors:||Ovidi, E.
Laghezza Masci, Valentina
|Journal:||NATURAL PRODUCT RESEARCH||Issue Date:||2019||Abstract:||
The aim of this study is to define chemical composition and antiproliferative activity of several compounds isolated from Schinus molle male and female flowers on human neuroblastoma (SH-SY5Y) and human leukemia (HL60) cell lines. Three extracts obtained by using solvents with different polarities (petroleum ether, diethyl ether and acetone) were characterized by GC/MS analysis revealing qualitative and quantitative differences in the chemical composition of male and female flowers. Nineteen components were identified and both flower extracts were dominated by the sesquiterpene hydrocarbons fraction, mainly elemol, followed by bicyclic sesquiterpenes and by a smaller amount of monoterpenes. The biological activities of the extracts were evaluated by dose-dependent viability assay on two different cell lines and HL60 cells resulted more sensitive to the treatment. The presence of compounds at low concentration with a well-established cytotoxic activity such as β-elemene, β-caryophyllene and γ-eudesmol could exert a synergistic cytotoxic effect.
|Appears in Collections:||A1. Articolo in rivista|
Show full item record
Files in This Item:
checked on Aug 3, 2022
checked on Aug 8, 2022
All documents in the "Unitus Open Access" community are published as open access.
All documents in the community "Prodotti della Ricerca" are restricted access unless otherwise indicated for specific documents