Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/47644
DC FieldValueLanguage
dc.contributor.authorBizzarri, Bruno Mattiait
dc.contributor.authorLorenzo Bottait
dc.contributor.authorCapecchi, Elianait
dc.contributor.authorCelestino, Ignacioit
dc.contributor.authorChecconi, Paolait
dc.contributor.authorPalamara, Anna Tit
dc.contributor.authorNencioni, Luciait
dc.contributor.authorSaladino, Raffaeleit
dc.date.accessioned2022-05-04T09:20:00Z-
dc.date.available2022-05-04T09:20:00Z-
dc.date.issued2017it
dc.identifier.issn1520-6025it
dc.identifier.urihttp://hdl.handle.net/2067/47644-
dc.description.abstractDifferent catechol and pyrogallol derivatives have been synthesized by oxidation of coumarins with 2-iodoxybenzoic acid (IBX) in DMSO at 25 °C. A high regioselectivity was observed in accordance with the stability order of the incipient carbocation or radical benzylic-like intermediate. The oxidation was also effective in water under heterogeneous conditions by using IBX supported on polystyrene. The new derivatives showed improved antioxidant effects in the DPPH test and inhibitory activity against the influenza A/PR8/H1N1 virus. These data represent a new entry for highly oxidized coumarins showing an antiviral activity possibly based on the control of the intracellular redox value.it
dc.language.isoengit
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleRegioselective IBX-Mediated Synthesis of Coumarin Derivatives with Antioxidant and Anti-influenza Activitiesit
dc.typearticle*
dc.identifier.doi10.1021/acs.jnatprod.7b00665it
dc.identifier.pmid29236486it
dc.identifier.scopus2-s2.0-85039148517it
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85039148517it
dc.relation.journalJOURNAL OF NATURAL PRODUCTSit
dc.relation.firstpage3247-3254it
dc.relation.lastpage3254it
dc.relation.volume80it
dc.relation.issue12it
dc.description.numberofauthors8it
dc.description.internationalnoit
dc.contributor.countryITAit
dc.type.refereeREF_1it
dc.type.miur262*
item.fulltextWith Fulltext-
item.openairetypearticle-
item.cerifentitytypePublications-
item.grantfulltextrestricted-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.journal.journalissn1520-6025-
crisitem.journal.anceE235950-
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