Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/47547
Title: Vaccination and immune responses of European sea bass (Dicentrarchus labrax L.) against betanodavirus
Authors: Buonocore, Francesco 
Nuñez-Ortiz, Noelia
Picchietti, Simona 
Randelli, Elisa
Stocchi, Valentina
Guerra, Laura
Toffan, Anna
Pascoli, Francesco
Fausto, Anna Maria 
Mazzini, Massimo
Scapigliati, Giuseppe 
Journal: FISH AND SHELLFISH IMMUNOLOGY 
Issue Date: 2019
Abstract: 
This review summarizes the available knowledge on the immune defences of European sea bass against antigenic preparations derived from the viral encephalopathy and retinopathy virus (betanodavirus), which represents a major threat to the health of this fish species. The nodavirus is widely present and differentiates into several strains that infect invertebrates (in insects, alphanodavirus) and teleost fish, and thus may represent a great problem for farmed fish species. Many efforts have been directed to discovering new immunizations to induce protection in sea bass, especially at young stages, and these efforts have included employing diverse betanodavirus strains, antigen preparation, vaccination routes, and the addition of adjuvants and/or immunostimulants. The obtained results showed that inactivated preparations of betanodavirus that were administered intraperitoneally may induce both immune recognition and protection. Attempts at performing mucosal immunization by immersion and/or oral administration, which is a vaccination route that is highly preferred for sea bass, have shown intriguing results, and more studies are necessary for its improvement. Overall, the objective of identifying a reliable vaccine that also cross-protects against different genotypes or reassortant viruses for use in European sea bass against betanodavirus appears to be an attainable goal in the near future.
URI: http://hdl.handle.net/2067/47547
ISSN: 1050-4648
DOI: 10.1016/j.fsi.2017.11.039
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Appears in Collections:A1. Articolo in rivista

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