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Title: Scientometric and Methodological Analysis of the Recent Literature on the Health-Related Effects of Tomato and Tomato Products.
Authors: Tilesi, Francesca
Picarella, Maurizio E.
Mazzucato A 
Journal: FOODS 
Issue Date: 2021
The health benefits of tomato, a vegetable consumed daily in human diets, have received
great attention in the scientific community, and a great deal of experiments have tested their utility
against several diseases. Herein, we present a scientometric analysis of recent works aimed to
estimate the biological effects of tomato, focusing on bibliographic metadata, type of testers, target
systems, and methods of analysis. A remarkably variable array of strategies was reported, including
testers obtained by standard and special tomatoes, and the use of in vitro and in vivo targets, both
healthy and diseased. In vitro, 21 normal and 36 cancer human cell lines derived from 13 different
organs were used. The highest cytotoxic effects were reported on cancer blood cells. In vivo, more
experiments were carried out with murine than with human systems, addressing healthy individuals,
as well as stressed and diseased patients. Multivariate analysis showed that publications in journals
indexed in the agriculture category were associated with the use of fresh tomatoes; conversely,
medicine and pharmacology journals were associated with the use of purified and formulate testers.
Studies conducted in the United States of America preferentially adopted in vivo systems and
formulates, combined with blood and tissue analysis. Researchers in Italy, China, India, and Great
Britain mostly carried out in vitro research using fresh tomatoes. Gene expression and proteomic
analyses were associated with China and India. The emerging scenario evidences the somewhat
dichotomic approaches of plant geneticists and agronomists and that of cell biologists and medicine
researchers. A higher integration between these two scientific communities would be desirable to
foster the assessment of the benefits of tomatoes to human health.
ISSN: 2304-8158
DOI: http://doi:10.3390/foods10081905
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Appears in Collections:A1. Articolo in rivista

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