Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/47270
Title: A gene expression atlas for different kinds of stress in the mouse brain
Authors: Flati, Tiziano
Gioiosa, Silvia
Chillemi, Giovanni 
Mele, Andrea
Oliverio, Alberto
Mannironi, Cecilia
Rinaldi, Arianna
Castrignano', Tiziana 
Journal: SCIENTIFIC DATA 
Issue Date: 2020
Abstract: 
Stressful experiences are part of everyday life and animals have evolved physiological and behavioral responses aimed at coping with stress and maintaining homeostasis. However, repeated or intense stress can induce maladaptive reactions leading to behavioral disorders. Adaptations in the brain, mediated by changes in gene expression, have a crucial role in the stress response. Recent years have seen a tremendous increase in studies on the transcriptional effects of stress. The input raw data are freely available from public repositories and represent a wealth of information for further global and integrative retrospective analyses. We downloaded from the Sequence Read Archive 751 samples (SRA-experiments), from 18 independent BioProjects studying the effects of different stressors on the brain transcriptome in mice. We performed a massive bioinformatics re-analysis applying a single, standardized pipeline for computing differential gene expression. This data mining allowed the identification of novel candidate stress-related genes and specific signatures associated with different stress conditions. The large amount of computational results produced was systematized in the interactive "Stress Mice Portal".
URI: http://hdl.handle.net/2067/47270
ISSN: 2052-4463
DOI: 10.1038/s41597-020-00772-z
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Appears in Collections:A1. Articolo in rivista

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