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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/47229
DC FieldValueLanguage
dc.contributor.authorGabellone, Sofiait
dc.contributor.authorPiccinino, Davideit
dc.contributor.authorFilippi, Silviait
dc.contributor.authorCastrignanò, Tizianait
dc.contributor.authorZippilli, Claudioit
dc.contributor.authorDel Buono, Davideit
dc.contributor.authorSaladino, Raffaeleit
dc.date.accessioned2022-03-22T13:15:47Z-
dc.date.available2022-03-22T13:15:47Z-
dc.date.issued2022it
dc.identifier.issn1422-0067it
dc.identifier.urihttp://hdl.handle.net/2067/47229-
dc.description.abstractWe report here the synthesis of novel thymine biomimetic photo-adducts bearing an alkane spacer between nucleobases and characterized by antimelanoma activity against two mutated cancer cell lines overexpressing human Topoisomerase 1 (TOP1), namely SKMEL28 and RPMI7951. Among them, Dewar Valence photo-adducts showed a selectivity index higher than the corresponding pyrimidine-(6-4)-pyrimidone and cyclobutane counterpart and were characterized by the highest affinity towards TOP1/DNA complex as evaluated by molecular docking analysis. The antimelanoma activity of novel photo-adducts was retained after loading into UV photo-protective lignin nanoparticles as stabilizing agent and efficient drug delivery system. Overall, these results support a combined antimelanoma and UV sunscreen strategy involving the use of photo-protective lignin nanoparticles for the controlled release of thymine dimers on the skin followed by their sacrificial transformation into photo-adducts and successive inhibition of melanoma and alert of cellular UV machinery repair pathways.it
dc.format.mediumELETTRONICOit
dc.language.isoengit
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleLignin Nanoparticles Deliver Novel Thymine Biomimetic Photo-Adducts with Antimelanoma Activityit
dc.typearticle*
dc.identifier.doi10.3390/ijms23020915it
dc.identifier.pmid35055101it
dc.identifier.scopus2-s2.0-85122823978it
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85122823978it
dc.relation.journalINTERNATIONAL JOURNAL OF MOLECULAR SCIENCESit
dc.relation.firstpage915it
dc.relation.volume23it
dc.relation.issue2it
dc.description.internationalnoit
dc.contributor.countryITAit
dc.type.refereeREF_1it
dc.type.miur262*
item.fulltextWith Fulltext-
item.openairetypearticle-
item.cerifentitytypePublications-
item.grantfulltextrestricted-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.journal.journalissn1422-0067-
crisitem.journal.anceE184525-
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