Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/46940
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dc.contributor.authorCatalani Elisabettait
dc.contributor.authorFanelli, Giuseppinait
dc.contributor.authorSilvestri, Federicait
dc.contributor.authorCherubini, Agneseit
dc.contributor.authorDel Quondam, Simonait
dc.contributor.authorBongiorni, Silviait
dc.contributor.authorTaddei, Anna Ritait
dc.contributor.authorCeci, Marcelloit
dc.contributor.authorDe Palma, Clarait
dc.contributor.authorPerrotta, Cristianait
dc.contributor.authorRinalducci, Sarait
dc.contributor.authorPrantera, Giorgioit
dc.contributor.authorCervia, Davideit
dc.date.accessioned2022-02-24T14:09:36Z-
dc.date.available2022-02-24T14:09:36Z-
dc.date.issued2021it
dc.identifier.issn2076-3921it
dc.identifier.urihttp://hdl.handle.net/2067/46940-
dc.description.abstractAberrant production of reactive oxygen species (ROS) is a common feature of damaged retinal neurons in diabetic retinopathy, and antioxidants may exert both preventive and therapeutic action. To evaluate the beneficial and antioxidant properties of food supplementation with Lisosan G, a powder of bran and germ of grain (Triticum aestivum) obtained by fermentation with selected lactobacillus and natural yeast strains, we used an in vivo model of hyperglycemia-induced retinal damage, the fruit fly Drosophila melanogaster fed with high-sucrose diet. Lisosan G positively affected the visual system of hyperglycemic flies at structural/functional level, decreased apoptosis, and reactivated protective autophagy at the retina internal network. Also, in high sucrose-fed Drosophila, Lisosan G reduced the levels of brain ROS and retina peroxynitrite. The analysis of oxidative stress-related metabolites suggested 7,8-dihydrofolate, uric acid, dihydroorotate, γ-L-glutamyl-L-cysteine, allantoin, cysteinyl-glycine, and quinolate as key mediators of Lisosan G-induced inhibition of neuronal ROS, along with the upregulation of glutathione system. Of note, Lisosan G may impact oxidative stress and the ensuing retinal cell death, also independently from autophagy, although the autophagy-ROS cross-talk is critical. This study demonstrated that the continuous supplementation with the alimentary integrator Lisosan G exerts a robust and multifaceted antioxidant effect on retinal neurons, thus providing efficacious neuroprotection of hyperglycemic eye.it
dc.format.mediumELETTRONICOit
dc.language.isoengit
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleNutraceutical Strategy to Counteract Eye Neurodegeneration and Oxidative Stress in Drosophila melanogaster Fed with High-Sugar Dietit
dc.typearticle*
dc.identifier.doi10.3390/antiox10081197it
dc.identifier.pmid34439445it
dc.identifier.scopus2-s2.0-85111106768it
dc.identifier.isi000688584700001it
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388935/it
dc.relation.journalANTIOXIDANTSit
dc.relation.article1197it
dc.relation.volume10it
dc.relation.issue8it
dc.description.internationalnoit
dc.contributor.countryITAit
dc.type.refereeREF_1it
dc.type.miur262*
item.openairetypearticle-
item.grantfulltextrestricted-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.journal.journalissn2076-3921-
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