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http://hdl.handle.net/2067/46863
DC Field | Value | Language |
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dc.contributor.author | Elisa Ovidi | it |
dc.contributor.author | Masci, Valentina Laghezza | it |
dc.contributor.author | Taddei, Anna Rita | it |
dc.contributor.author | Paolicelli, Patrizia | it |
dc.contributor.author | Petralito, Stefania | it |
dc.contributor.author | Trilli, Jordan | it |
dc.contributor.author | Mastrogiovanni, Fabio | it |
dc.contributor.author | Tiezzi, Antonio | it |
dc.contributor.author | Casadei, Maria Antonietta | it |
dc.contributor.author | Giacomello, Pierluigi | it |
dc.contributor.author | Garzoli, Stefania | it |
dc.date.accessioned | 2022-02-15T11:54:28Z | - |
dc.date.available | 2022-02-15T11:54:28Z | - |
dc.date.issued | 2020 | it |
dc.identifier.issn | 1424-8247 | it |
dc.identifier.uri | http://hdl.handle.net/2067/46863 | - |
dc.description.abstract | Lavandin essential oil (LEO), a natural sterile hybrid obtained by crossbreeding L. angustifolia × L. latifolia, is mainly composed by active components belonging to the family of terpenes endowed with relevant anti-proliferative activity, which can be enhanced by proper application of nanotechnology. In particular, this study reports the chemical characterization and the screening of the anti-proliferative activity on different human cell lines of pure and nano-formulated lavandin essential oil (EO). LEO and its formulation (NanoLEO) were analyzed by HS/GC-MS (Headspace/Gas Chromatography-Mass Spectrometry) to describe and compare their chemical volatile composition. The most abundant compounds were linalool and 1,8-cineole (LEO: 28.6%; 27.4%) (NanoLEO: 60.4%; 12.6%) followed by α-pinene (LEO: 9.6%; NanoLEO: 4.5%), camphor (LEO: 6.5%; NanoLEO: 7.0%) and linalyl acetate (LEO: 6.5%; NanoLEO: 3.6%). The cytotoxic effects of LEO and NanoLEO were investigated on human neuroblastoma cells (SHSY5Y), human breast adenocarcinoma cells (MCF-7), human lymphoblastic leukemia cells (CCRF CEM), human colorectal adenocarcinoma cells (Caco-2) and one normal breast epithelial cell (MCF10A) by the MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide)-assay. Caco-2, MCF7 and MCF10A normal cells resulted more resistant to the treatment with LEO, while CCRF-CEM and SHSY5Y cells were more sensitive. The antiproliferative effect of LEO resulted amplified when the essential oil was supplied as nanoformulation, mainly in Caco-2 cells. Scanning and transmission electron microscopy investigations were carried out on Caco-2 cells to outline at ultrastructural level possible affections induced by LEO and NanoLEO treatments. | it |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Chemical Investigation and Screening of Anti-Proliferative Activity on Human Cell Lines of Pure and Nano-Formulated Lavandin Essential Oil | it |
dc.type | article | * |
dc.identifier.doi | 10.3390/ph13110352 | it |
dc.identifier.pmid | 33138099 | it |
dc.identifier.scopus | 2-s2.0-85094615112 | it |
dc.identifier.url | https://dspace.unitus.it/handle/2067/44054 | it |
dc.relation.journal | PHARMACEUTICALS | it |
dc.relation.firstpage | 1 | it |
dc.relation.lastpage | 17 | it |
dc.relation.volume | 13 | it |
dc.relation.issue | 11 | it |
dc.type.miur | 262 | * |
item.fulltext | With Fulltext | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | restricted | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.orcid | https://orcid.org/0000-0001-8876-6331 | - |
crisitem.journal.journalissn | 1424-8247 | - |
crisitem.journal.ance | E199974 | - |
Appears in Collections: | A1. Articolo in rivista |
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File | Description | Size | Format | Existing users please |
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pharmaceuticals-13-00352.pdf | 4.08 MB | Adobe PDF | Request a copy |
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