Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/46438
DC FieldValueLanguage
dc.contributor.authorImperlini, Estherit
dc.contributor.authorCelia, Christianit
dc.contributor.authorCevenini, Armandoit
dc.contributor.authorMandola, Annalisait
dc.contributor.authorRaia, Maddalenait
dc.contributor.authorFresta, Massimoit
dc.contributor.authorOrrù, Stefaniait
dc.contributor.authorDi Marzio, Luisait
dc.contributor.authorSalvatore, Francescoit
dc.date.accessioned2022-01-21T11:44:24Z-
dc.date.available2022-01-21T11:44:24Z-
dc.date.issued2021it
dc.identifier.issn2040-3372it
dc.identifier.urihttp://hdl.handle.net/2067/46438-
dc.description.abstractUnraveling the proteins interacting with nanoparticles (NPs) in biological fluids, such as blood, is pivotal to rationally design NPs for drug delivery. The protein corona (PrC), formed on the NP surface, represents an interface between biological components and NPs, dictating their pharmacokinetics and biodistribution. PrC composition depends on biological environments around NPs and on their intrinsic physicochemical properties. We generated different formulations of non-ionic surfactant/non-phospholipid vesicles, called niosomes (NIOs), using polysorbates which are biologically safe, cheap, non-toxic and scarcely immunogenic. PrC composition and relative protein abundance for all designed NIOs were evaluated ex vivo in human plasma (HP) by quantitative label-free proteomics. We studied the correlation of the relative protein abundance in the corona with cellular uptake of the PrC-NIOs in healthy and cancer human cell lines. Our results highlight the effects of polysorbates on nano-bio interactions to identify a protein pattern most properly aimed to drive the NIO targeting in vivo, and assess the best conditions of PrC-NIO NP uptake into the cells. This study dissected the biological identity in HP of polysorbate-NIOs, thus contributing to shorten their passage from preclinical to clinical studies and to lay the foundations for a personalized PrC.it
dc.language.isoengit
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.titleNano-bio interface between human plasma and niosomes with different formulations indicates protein corona patterns for nanoparticle cell targeting and uptakeit
dc.typearticle*
dc.identifier.doi10.1039/d0nr07229jit
dc.identifier.pmid33666624it
dc.identifier.scopus2-s2.0-85102870832it
dc.relation.journalNANOSCALEit
dc.relation.firstpage5251-5269it
dc.relation.lastpage5269it
dc.relation.volume13it
dc.relation.issue10it
dc.subject.scientificsectorBIO/10it
dc.contributor.countryITAit
dc.type.refereeREF_1it
dc.type.miur262*
item.fulltextWith Fulltext-
item.openairetypearticle-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.journal.journalissn2040-3372-
crisitem.journal.anceE235870-
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