Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/46169
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dc.contributor.authorMastrogiovanni, Fabioit
dc.contributor.authorRomani, Annalisait
dc.contributor.authorSanti, Lucait
dc.contributor.authorLacetera, Nicolait
dc.contributor.authorBernini, Robertait
dc.date.accessioned2021-11-10T13:10:54Z-
dc.date.available2021-11-10T13:10:54Z-
dc.date.issued2019it
dc.identifier.issn1478-6427it
dc.identifier.urihttp://hdl.handle.net/2067/46169-
dc.description.abstractPomegranate peel extracts prepared in our laboratories from a waste of juice fruit processing were tested on bovine peripheral blood mononuclear cells to evaluate the effects on viability, oxidative stress and proliferation. The (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay pointed out that the extracts were not cytotoxic at the tested concentrations (0.1, 1.0, and 10 µg/mL). A moderate protective effect against Reactive Oxygen Species production induced by hydrogen peroxide or lipopolysaccharide and a significant anti-proliferative activity against proliferation induced by concanavalin A were observed on cell lines treated with the extracts at 10 μg/mL. Based on these results, pomegranate peel extracts seem promising as feed supplement for dairy cattle, in particular around calving, when the animals are subjected to an increase of the metabolic activity, responsible for oxidative stress and diseases. However, in vivo studies are needed to investigate the stability of the extracts across the bovine gastrointestinal tract barrier.it
dc.titleAnti-proliferative effect of pomegranate peel extracts on bovine peripheral blood mononuclear cells (PBMCs)it
dc.typearticle*
dc.identifier.doi10.1080/14786419.2019.1627350it
dc.identifier.pmid31180248it
dc.identifier.scopus2-s2.0-85067576426it
dc.identifier.urlhttps://www.tandfonline.com/doi/abs/10.1080/14786419.2019.1627350?journalCode=gnpl20it
dc.relation.journalNATURAL PRODUCT RESEARCHit
dc.relation.firstpage1696it
dc.relation.lastpage1701it
dc.relation.volume35it
dc.relation.issue10it
dc.description.internationalnoit
dc.contributor.countryITAit
dc.type.miur262*
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.grantfulltextrestricted-
item.openairetypearticle-
crisitem.journal.journalissn1478-6427-
crisitem.journal.anceE200663-
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