Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/46078
Title: Src tyrosine kinase inhibitor and X-rays combined effect on glioblastoma cell lines
Authors: Torrisi, Filippo
Minafra, Luigi
Cammarata, Francesco P.
Savoca, Gaetano
Calvaruso, Marco
Vicario, Nunzio
Maccari, Laura
Pérès, Elodie A.
Özçelik, Hayriye
Bernaudin, Myriam
botta, lorenzo 
Russo, Giorgio
Parenti, Rosalba
Valable, Samuel
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 
Issue Date: 2020
Abstract: 
Glioblastoma (GBM) is one of the most lethal types of tumor due to its high recurrence level in spite of aggressive treatment regimens involving surgery, radiotherapy and chemotherapy. Hypoxia is a feature of GBM, involved in radioresistance, and is known to be at the origin of treatment failure. The aim of this work was to assess the therapeutic potential of a new targeted c-SRC inhibitor molecule, named Si306, in combination with X-rays on the human glioblastoma cell lines, comparing normoxia and hypoxia conditions. For this purpose, the dose modifying factor and oxygen enhancement ratio were calculated to evaluate the Si306 radiosensitizing effect. DNA damage and the repair capability were also studied from the kinetic of γ-H2AX immunodetection. Furthermore, motility processes being supposed to be triggered by hypoxia and irradiation, the role of c-SRC inhibition was also analyzed to evaluate the migration blockage by wound healing assay. Our results showed that inhibition of the c-SRC protein enhances the radiotherapy efficacy both in normoxic and hypoxic conditions. These data open new opportunities for GBM treatment combining radiotherapy with molecularly targeted drugs to overcome radioresistance.
URI: http://hdl.handle.net/2067/46078
ISSN: 1661-6596
DOI: 10.3390/ijms21113917
Rights: Attribution-NonCommercial-NoDerivs 3.0 United States
Appears in Collections:A1. Articolo in rivista

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