Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/43717
Title: Mass of genes rather than master genes underlie the genomic architecture of amphibian speciation
Authors: Dufresnes, Christophe
Brelsford, Alan
Jeffries, Daniel L.
Mazepa, Glib
Suchan, Tomasz
Canestrelli, Daniele 
Nicieza, Alfredo
Fumagalli, Luca
Dubey, Sylvain
Martínez-Solano, Iñigo
Litvinchuk, Spartak N.
Vences, Miguel
Perrin, Nicolas
Crochet, Pierre André
Journal: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 
Issue Date: 2021
Abstract: 
The genetic architecture of speciation, i.e., how intrinsic genomic incompatibilities promote reproductive isolation (RI) between diverging lineages, is one of the best-kept secrets of evolution. To directly assess whether incompatibilities arise in a limited set of large-effect speciation genes, or in a multitude of loci, we examined the geographic and genomic landscapes of introgression across the hybrid zones of 41 pairs of frog and toad lineages in the Western Palearctic region. As the divergence between lineages increases, phylogeographic transitions progressively become narrower, and larger parts of the genome resist introgression. This suggests that anuran speciation proceeds through a gradual accumulation of multiple barrier loci scattered across the genome, which ultimately deplete hybrid fitness by intrinsic postzygotic isolation, with behavioral isolation being achieved only at later stages. Moreover, these loci were disproportionately sex linked in one group (Hyla) but not in others (Rana and Bufotes), implying that large X-effects are not necessarily a rule of speciation with undifferentiated sex chromosomes. The highly polygenic nature of RI and the lack of hemizygous X/Z chromosomes could explain why the speciation clock ticks slower in amphibians compared to other vertebrates. The clock-like dynamics of speciation combined with the analytical focus on hybrid zones offer perspectives for more standardized practices of species delimitation.
URI: http://hdl.handle.net/2067/43717
ISSN: 1091-6490
DOI: 10.1073/pnas.2103963118
Appears in Collections:A1. Articolo in rivista

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