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Title: The sea bass Dicentrarchus labrax as a marine model species in immunology: Insights from basic and applied research
Authors: Miccoli, Andrea 
Buonocore, Francesco 
Picchietti, Simona 
Scapigliati, Giuseppe 
Issue Date: 2021
This review summarizes the current knowledge on immune defence activities of the European sea bass Dicentrarchus
labrax by reporting the consistent amount of work done on this economically-important species. A draft
genome sequence is available for this species, together with whole transcriptomes from lymphoid and nonlymphoid
tissues. Available full-length coding sequences of many immunoregulatory and immune-related
genes allow for targeted quantitative PCR analysis, nowadays needed for -omics data verification, ex vivo and
in vitro. The first anti-T cells monoclonal antibody teleost-wise was obtained in sea bass, followed by several
monoclonal and polyclonal markers of lymphocyte populations, namely T cells (pan-T, CD3ε, TcRγ, CD45), and B
cells (IgM, IgT, IgD). The combined use of molecular and biochemical tools enabled investigations on innate and
acquired immune responses of sea bass in unstimulated/stimulated fish, along the development and under
variable environmental conditions and food regimes. An overview of sea bass viral and bacterial pathogens and
available vaccines against these microorganisms is also provided. The knowledge accumulated in the past 25
years validates the European sea bass as a reference marine model in the field of fish immunology.
ISSN: 2468-550X
DOI: 10.1016/j.aaf.2021.09.003
Rights: Attribution-NonCommercial-ShareAlike 3.0 United States
Appears in Collections:A1. Articolo in rivista

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