Please use this identifier to cite or link to this item:
http://hdl.handle.net/2067/43501
DC Field | Value | Language |
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dc.contributor.author | Assi, Emma | it |
dc.contributor.author | Cervia, Davide | it |
dc.contributor.author | Bizzozero, Laura | it |
dc.contributor.author | Capobianco, Annalisa | it |
dc.contributor.author | Pambianco, Sarah | it |
dc.contributor.author | Morisi, Federica | it |
dc.contributor.author | De Palma, Clara | it |
dc.contributor.author | Moscheni, Claudia | it |
dc.contributor.author | Pellegrino, Paolo | it |
dc.contributor.author | Clementi, Emilio | it |
dc.contributor.author | Perrotta, Cristiana | it |
dc.date.accessioned | 2021-06-11T10:38:21Z | - |
dc.date.available | 2021-06-11T10:38:21Z | - |
dc.date.issued | 2015 | it |
dc.identifier.issn | 0962-9351 | it |
dc.identifier.uri | http://hdl.handle.net/2067/43501 | - |
dc.description.abstract | The inflammatory microenvironment induces tumours to acquire an aggressive and immunosuppressive behaviour. Since acid sphingomyelinase (A-SMase) downregulation in melanoma was shown to determine a malignant phenotype, we aimed here to elucidate the role of A-SMase in the regulation of tumour immunogenic microenvironment using in vivo melanoma models in which A-SMase was either downregulated or maintained at constitutively high levels. We found high levels of inflammatory factors in low A-SMase expressing tumours, which also displayed an immunosuppressive/protumoural microenvironment: high levels of myeloid-derived suppressor cells (MDSCs) and regulatory T lymphocytes (Tregs), as well as low levels of dendritic cells (DCs). In contrast, the restoration of A-SMase in melanoma cells not only reduced tumour growth and immunosuppression, but also induced a high recruitment at tumour site of effector immune cells with an antitumoural function. Indeed, we observed a poor homing of MDSCs and Tregs and the increased recruitment of CD8(+) and CD4(+) T lymphocytes as well as the infiltration of DCs and CD8(+)/CD44(high) T lymphocytes. This study demonstrates that change of A-SMase expression in cancer cells is sufficient per se to tune in vivo melanoma growth and that A-SMase levels modulate immune cells at tumour site. This may be taken into consideration in the setting of therapeutic strategies. | it |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.title | Modulation of Acid Sphingomyelinase in Melanoma Reprogrammes the Tumour Immune Microenvironment | it |
dc.type | article | * |
dc.identifier.doi | 10.1155/2015/370482 | it |
dc.identifier.pmid | 26101462 | it |
dc.identifier.scopus | 2-s2.0-84935830836 | it |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84935830836 | it |
dc.relation.journal | MEDIATORS OF INFLAMMATION | it |
dc.relation.firstpage | 370482 | it |
dc.relation.lastpage | 13 | it |
dc.relation.volume | 2015 | it |
dc.type.miur | 262 | * |
item.fulltext | With Fulltext | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | restricted | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.journal.journalissn | 0962-9351 | - |
crisitem.journal.ance | E107669 | - |
Appears in Collections: | A1. Articolo in rivista |
Files in This Item:
File | Description | Size | Format | Existing users please |
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Assi et al Mediators Inflamm 2015.pdf | 3.27 MB | Adobe PDF | Request a copy |
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