Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2067/43494
Campo DCValoreLingua
dc.contributor.authorCoazzoli, Marcoit
dc.contributor.authorNapoli, Alessandrait
dc.contributor.authorRoux-Biejat, Paulinait
dc.contributor.authorPalma, Clara Deit
dc.contributor.authorMoscheni, Claudiait
dc.contributor.authorCatalani Elisabettait
dc.contributor.authorZecchini, Silviait
dc.contributor.authorConte, Vincenzoit
dc.contributor.authorGiovarelli, Matteoit
dc.contributor.authorCaccia, Soniait
dc.contributor.authorProcacci, Patriziait
dc.contributor.authorCervia, Davideit
dc.contributor.authorClementi, Emilioit
dc.contributor.authorPerrotta, Cristianait
dc.date.accessioned2021-06-11T10:19:15Z-
dc.date.available2021-06-11T10:19:15Z-
dc.date.issued2020it
dc.identifier.issn2073-4409it
dc.identifier.urihttp://hdl.handle.net/2067/43494-
dc.description.abstractMelanoma is the most severe type of skin cancer. Its unique and heterogeneous metabolism, relying on both glycolysis and oxidative phosphorylation, allows it to adapt to disparate conditions. Mitochondrial function is strictly interconnected with mitochondrial dynamics and both are fundamental in tumour progression and metastasis. The malignant phenotype of melanoma is also regulated by the expression levels of the enzyme acid sphingomyelinase (A-SMase). By modulating at transcriptional level A-SMase in the melanoma cell line B16-F1 cells, we assessed the effect of enzyme downregulation on mitochondrial dynamics and function. Our results demonstrate that A-SMase influences mitochondrial morphology by affecting the expression of mitofusin 1 and OPA1. The enhanced expression of the two mitochondrial fusion proteins, observed when A-SMase is expressed at low levels, correlates with the increase of mitochondrial function via the stimulation of the genes PGC-1alpha and TFAM, two genes that preside over mitochondrial biogenesis. Thus, the reduction of A-SMase expression, observed in malignant melanomas, may determine their metastatic behaviour through the stimulation of mitochondrial fusion, activity and biogenesis, conferring a metabolic advantage to melanoma cells.it
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.titleAcid Sphingomyelinase Downregulation Enhances Mitochondrial Fusion and Promotes Oxidative Metabolism in a Mouse Model of Melanomait
dc.typearticle*
dc.identifier.doi10.3390/cells9040848it
dc.identifier.pmid32244541it
dc.identifier.scopus2-s2.0-85102394534it
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85102394534it
dc.relation.journalCELLSit
dc.relation.firstpage848it
dc.relation.volume9it
dc.relation.issue4it
dc.type.miur262*
item.grantfulltextrestricted-
item.openairetypearticle-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.journal.journalissn2073-4409-
crisitem.journal.anceE217337-
È visualizzato nelle collezioni:A1. Articolo in rivista
File in questo documento:
File Descrizione DimensioniFormato Existing users please
Coazzoli et al Cells 2020.pdf6.73 MBAdobe PDF  Richiedi una copia
Visualizza la scheda semplice del documento

SCOPUSTM
Citations 10

3
Last Week
0
Last month
0
controllato il 17-mag-2022

Page view(s)

14
Last Week
0
Last month
0
controllato il 23-mag-2022

Download(s)

1
controllato il 23-mag-2022

Google ScholarTM

Check

Altmetric


Questo documento è distribuito in accordo con Licenza Creative Commons Creative Commons