Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/43492
Title: Natural Function and Structural Modification of Climacostol, a Ciliate Secondary Metabolite
Authors: Buonanno, Federico
Catalani Elisabetta 
Cervia, Davide 
Cimarelli, Cristina
Marcantoni, Enrico
Ortenzi, Claudio
Journal: MICROORGANISMS 
Issue Date: 2020
Abstract: 
The review highlights the main results of two decades of research on climacostol (5-[(2Z)-non-2-en-1-yl]benzene-1,3-diol), the resorcinolic lipid produced and used by the ciliated protozoan Climacostomumvirens for chemical defense against a wide range of predators, and to assist its carnivorous feeding. After the first studies on the physiological function of climacostol, the compound and some analogues were chemically synthesized, thus allowing us to explore both its effect on different prokaryotic and eukaryotic biological systems, and the role of its relevant structural traits. In particular, the results obtained in the last 10 years indicate climacostol is an effective antimicrobial and anticancer agent, bringing new clues to the attempt to design and synthesize additional novel analogues that can increase or optimize its pharmacological properties.
URI: http://hdl.handle.net/2067/43492
ISSN: 2076-2607
DOI: 10.3390/microorganisms8060809
Rights: Attribution-NonCommercial-NoDerivs 3.0 United States
Appears in Collections:A1. Articolo in rivista

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