Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/43462
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dc.contributor.authorGeisslitz, Sabrinait
dc.contributor.authorShewry, Peterit
dc.contributor.authorBrouns, Fredit
dc.contributor.authorAmerica, Antoine H. P.it
dc.contributor.authorCaio, Giacomo Pietro Ismaeleit
dc.contributor.authorDaly, Matthewit
dc.contributor.authorD'Amico, Stefanoit
dc.contributor.authorDe Giorgio, Robertoit
dc.contributor.authorGilissen, Luudit
dc.contributor.authorGrausgruber, Heinrichit
dc.contributor.authorHuang, Xinit
dc.contributor.authorJonkers, Daisyit
dc.contributor.authorKeszthelyi, Danielit
dc.contributor.authorLarré, Coletteit
dc.contributor.authorMasci, Stefaniait
dc.contributor.authorMills, Clareit
dc.contributor.authorMøller, Marie Sofieit
dc.contributor.authorSorrells, Mark E.it
dc.contributor.authorSvensson, Birteit
dc.contributor.authorZevallos, Victor F.it
dc.contributor.authorWeegels, Peter Louisit
dc.date.accessioned2021-05-31T10:28:44Z-
dc.date.available2021-05-31T10:28:44Z-
dc.date.issued2021it
dc.identifier.issn2296-861Xit
dc.identifier.urihttp://hdl.handle.net/2067/43462-
dc.description.abstractAmylase/trypsin-inhibitors (ATIs) comprise about 2–4% of the total wheat grain proteins and may contribute to natural defense against pests and pathogens. However, they are currently among the most widely studied wheat components because of their proposed role in adverse reactions to wheat consumption in humans. ATIs have long been known to contribute to IgE-mediated allergy (notably Bakers’ asthma), but interest has increased since 2012 when they were shown to be able to trigger the innate immune system, with attention focused on their role in coeliac disease which affects about 1%of the population and, more recently, in non-coeliac wheat sensitivity which may affect up to 10% of the population. This has led to studies of their structure, inhibitory properties, genetics, control of expression, behavior during processing, effects on human adverse reactions to wheat and, most recently, strategies to modify their expression in the plant using gene editing. We therefore present an integrated account of this range of research, identifying inconsistencies, and gaps in our knowledge and identifying future research needsit
dc.format.mediumELETTRONICOit
dc.language.isoengit
dc.rightsCC0 1.0 Universal*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.titleWheat ATIs: Characteristics and Role in Human Diseaseit
dc.typearticle*
dc.identifier.doi10.3389/fnut.2021.667370it
dc.relation.journalFRONTIERS IN NUTRITIONit
dc.relation.numberofpages16it
dc.relation.article667370it
dc.relation.volume8it
dc.subject.keywordswheat, amylase/trypsin-inhibitors, health, pathology, food technology, geneticsit
dc.description.internationalit
dc.type.refereeREF_1it
dc.type.miur262*
item.fulltextWith Fulltext-
item.openairetypearticle-
item.cerifentitytypePublications-
item.grantfulltextrestricted-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.journal.journalissn2296-861X-
crisitem.journal.anceE226909-
Appears in Collections:A1. Articolo in rivista
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