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Title: RNA Editing Detection in HPC Infrastructures
Authors: Lo Giudice, Claudio
Mansi, Luigi
Flati, Tiziano
Gioiosa, Silvia
Chillemi, Giovanni 
Libro, Pietro
Castrignan√≤, Tiziana 
Pesole, Graziano
Picardi, Ernesto
Issue Date: 2021
RNA editing by A-to-I deamination is a relevant co/posttranscriptional modification carried out by ADAR enzymes. In humans, it has pivotal cellular effects and its deregulation has been linked to a variety of human disorders including neurological and neurodegenerative diseases and cancer. Despite its biological relevance, the detection of RNA editing variants in large transcriptome sequencing experiments (RNAseq) is yet a challenging computational task. To drastically reduce computing times we have developed a novel REDItools version able to identify A-to-I events in huge amount of RNAseq data employing High Performance Computing (HPC) infrastructures.Here we show how to use REDItools v2 in HPC systems.
ISBN: 978-1-0716-1306-1
DOI: 10.1007/978-1-0716-1307-8_14
Appears in Collections:B1. Contributo in volume (Capitolo o Saggio)

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