Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2067/43366
Titolo: Dissecting the Gene Expression Networks Associated with Variations in the Major Components of the Fatty Acid Semimembranosus Muscle Profile in Large White Heavy Pigs
Autori: Zappaterra, Martina
Gioiosa, Silvia
Chillemi, Giovanni 
Zambonelli, Paolo
Davoli, Roberta
Rivista: ANIMALS 
Data pubblicazione: 2021
Abstract: 
To date, high-throughput technology such as RNA-sequencing has been successfully applied in livestock sciences to investigate molecular networks involved in complex traits, such as meat quality. Pork quality depends on several organoleptic, technological, and nutritional characteristics, and it is also influenced by the fatty acid (FA) composition of intramuscular fat (IMF). To explore the molecular networks associated with different IMF FA compositions, the Semimembranosus muscle (SM) from two groups of Italian Large White (ILW) heavy pigs divergent for SM IMF content was investigated using transcriptome analysis. After alignment and normalization, the obtained gene counts were used to perform the Weighted Correlation Network Analysis (WGCNA package in R environment). Palmitic and palmitoleic contents showed association with the same gene modules, comprising genes significantly enriched in autophagy, mitochondrial fusion, and mitochondrial activity. Among the key genes related to these FAs, we found TEAD4, a gene regulating mitochondrial activity that seems to be a promising candidate for further studies. On the other hand, the genes comprised in the modules associated with the IMF contents of oleic, n-6, and n-3 polyunsaturated FAs (PUFAs) were significantly enriched in Mitogen-Activated Protein Kinase (MAPK) signaling, in agreement with previous studies suggesting that several MAPK players may have a primary role in regulating lipid deposition. These results give an insight into the molecular cascade associated with different IMF FA composition in ILW heavy pigs. Further studies are needed to validate the results and confirm whether some of the identified key genes may be effective candidates for pork quality.
URI: http://hdl.handle.net/2067/43366
ISSN: 2076-2615
DOI: 10.3390/ani11030628
È visualizzato nelle collezioni:A1. Articolo in rivista

File in questo documento:
File Descrizione DimensioniFormato Existing users please
animals-11-00628-v2.pdf1.56 MBAdobe PDF  Richiedi una copia
Visualizza tutti i metadati del documento

Page view(s)

6
Last Week
0
Last month
1
controllato il 21-set-2021

Google ScholarTM

Check

Altmetric


Tutti i documenti nella community "Unitus Open Access" sono pubblicati ad accesso aperto.
Tutti i documenti nella community Prodotti della Ricerca" sono ad accesso riservato salvo diversa indicazione per alcuni documenti specifici