Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/43366
DC FieldValueLanguage
dc.contributor.authorZappaterra, Martinait
dc.contributor.authorGioiosa, Silviait
dc.contributor.authorChillemi, Giovanniit
dc.contributor.authorZambonelli, Paoloit
dc.contributor.authorDavoli, Robertait
dc.date.accessioned2021-04-22T14:40:05Z-
dc.date.available2021-04-22T14:40:05Z-
dc.date.issued2021it
dc.identifier.issn2076-2615it
dc.identifier.urihttp://hdl.handle.net/2067/43366-
dc.description.abstractTo date, high-throughput technology such as RNA-sequencing has been successfully applied in livestock sciences to investigate molecular networks involved in complex traits, such as meat quality. Pork quality depends on several organoleptic, technological, and nutritional characteristics, and it is also influenced by the fatty acid (FA) composition of intramuscular fat (IMF). To explore the molecular networks associated with different IMF FA compositions, the Semimembranosus muscle (SM) from two groups of Italian Large White (ILW) heavy pigs divergent for SM IMF content was investigated using transcriptome analysis. After alignment and normalization, the obtained gene counts were used to perform the Weighted Correlation Network Analysis (WGCNA package in R environment). Palmitic and palmitoleic contents showed association with the same gene modules, comprising genes significantly enriched in autophagy, mitochondrial fusion, and mitochondrial activity. Among the key genes related to these FAs, we found TEAD4, a gene regulating mitochondrial activity that seems to be a promising candidate for further studies. On the other hand, the genes comprised in the modules associated with the IMF contents of oleic, n-6, and n-3 polyunsaturated FAs (PUFAs) were significantly enriched in Mitogen-Activated Protein Kinase (MAPK) signaling, in agreement with previous studies suggesting that several MAPK players may have a primary role in regulating lipid deposition. These results give an insight into the molecular cascade associated with different IMF FA composition in ILW heavy pigs. Further studies are needed to validate the results and confirm whether some of the identified key genes may be effective candidates for pork quality.it
dc.format.mediumSTAMPAit
dc.language.isoengit
dc.titleDissecting the Gene Expression Networks Associated with Variations in the Major Components of the Fatty Acid Semimembranosus Muscle Profile in Large White Heavy Pigsit
dc.typearticle*
dc.identifier.doi10.3390/ani11030628it
dc.identifier.pmid33673460it
dc.identifier.scopus2-s2.0-85101712250it
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85101712250it
dc.relation.journalANIMALSit
dc.relation.firstpage1it
dc.relation.lastpage18it
dc.relation.volume11it
dc.relation.issue3it
dc.subject.scientificsectorAGR/17it
dc.subject.ercsectorLS9_3 Agriculture related to animal husbandry, dairying, livestock raisingit
dc.description.internationalnoit
dc.contributor.countryITAit
dc.type.refereeREF_1it
dc.type.miur262*
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
item.grantfulltextrestricted-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypearticle-
item.languageiso639-1en-
crisitem.journal.journalissn2076-2615-
crisitem.journal.anceE211799-
Appears in Collections:A1. Articolo in rivista
Files in This Item:
File Description SizeFormat Existing users please
animals-11-00628-v2.pdf1.56 MBAdobe PDF    Request a copy
Show simple item record

Page view(s)

5
Last Week
0
Last month
0
checked on Aug 4, 2021

Google ScholarTM

Check

Altmetric


All documents in the "Unitus Open Access" community are published as open access.
All documents in the community "Prodotti della Ricerca" are restricted access unless otherwise indicated for specific documents