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Title: Perspectives on Populus spp. (Salicaceae) bud extracts as antioxidant and anti-inflammatory agents
Authors: Pannucci, Elisa
D'Eliseo, Donatella
Ieri, Francesca
Romani, Annalisa
Santi, Luca 
Bernini, Roberta 
Sabatti, Maurizio 
Velotti, Francesca Romana 
Issue Date: 2021
Hydroalcoholic extracts obtained from buds of P. nigra, P. deltoides and P. trichocarpa were characterized by HPLC-DAD-MS analysis and subsequently evaluated in vitro for their antioxidant and anti-inflammatory activities. ABTS and DPPH assays evidenced that P. nigra showed the best antioxidant activity in line with its highest total phenolic content. The analysis of the anti-inflammatory activity clearly demonstrated that all extracts suppressed the production of key pro-inflammatory cytokines (IL-6, Il-1β and TNF-α) and HMGB1 inflammatory danger signal. These results show antioxidant and critical anti-inflammatory activities mediated by the extracts, emphasising their potentiality as therapeutic agents.
ISSN: 1478-6419
DOI: 10.1080/14786419.2021.1896512
Appears in Collections:A1. Articolo in rivista

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