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http://hdl.handle.net/2067/43126| Title: | Laccase-Catalyzed 1,4-Dioxane-Mediated Synthesis of Belladine N-Oxides with Anti-Influenza A Virus Activity | Authors: | Claudio Zippilli botta, lorenzo Bizzarri , B. M. Lucia Nencioni Marta De Angelis Virginia Protto Gianluca Giorgi Maria Camilla Baratto Rebecca Pogni Saladino, Raffaele |
Journal: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | Issue Date: | 2021 | Abstract: | Belladine N-oxides active against influenza A virus have been synthetized by a novel laccase-catalyzed 1,4-dioxane-mediated oxidation of aromatic and side-chain modified belladine derivatives. Electron paramagnetic resonance (EPR) analysis confirmed the role of 1,4-dioxane as a co-oxidant. The reaction was chemo-selective, showing a high functional-group compatibility. The novel belladine N-oxides were active against influenza A virus, involving the early stage of the virus replication life cycle |
URI: | http://hdl.handle.net/2067/43126 | ISSN: | 1661-6596 | DOI: | doi.org/10.3390/ijms22031337 | Rights: | CC0 1.0 Universal |
| Appears in Collections: | A1. Articolo in rivista |
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| File | Description | Size | Format | Existing users please |
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| ijms-22-01337-v2.pdf | Laccase-Catalyzed 1,4-Dioxane-Mediated Synthesis of Belladine N-Oxides with Anti-Influenza A Virus Activity | 2.13 MB | Adobe PDF | Request a copy |
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