Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/42942
Title: The role of RNA-binding and ribosomal proteins as specific RNA translation regulators in cellular differentiation and carcinogenesis
Authors: Ceci, Marcello 
Fazi, Francesco
Romano, Nicla 
Journal: BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE 
Issue Date: 2021
Abstract: 
Tight control of mRNA expression is required for cell differentiation; imbalanced regulation may lead to developmental disorders and cancer. The activity of the translational machinery (including ribosomes and translation factors) regulates the rate (slow or fast) of translation of encoded proteins, and the quality of these proteins highly depends on which mRNAs are available for translation. Specific RNA-binding and ribosomal proteins seem to play a key role in controlling gene expression to determine the differentiation fate of the cell. This demonstrates the important role of RNA-binding proteins, specific ribosome-binding proteins and microRNAs as key molecules in controlling the specific proteins required for the differentiation or dedifferentiation of cells. This delicate balance between specific proteins (in terms of quality and availability) and post-translational modifications occurring in the cytoplasm is crucial for cell differentiation, dedifferentiation and oncogenic potential. In this review, we report how defects in the regulation of mRNA translation can be dependent on specific proteins and can induce an imbalance between differentiation and dedifferentiation in cell fate determination.
URI: http://hdl.handle.net/2067/42942
ISSN: 1879-260X
DOI: 10.1016/j.bbadis.2020.166046
Appears in Collections:A1. Articolo in rivista

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