Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/42817
Title: Anti-inflammatory effects of pomegranate peel extracts on in vitro human intestinal Caco-2 cells and ex vivo porcine colonic tissue explants
Authors: Mastrogiovanni, Fabio
Mukhopadhya, Anindya
Lacetera, Nicola
Ryan, Maryon T
Romani, Annalisa
Bernini, Roberta 
Sweeney, Torres
Journal: NUTRIENTS 
Issue Date: 2019
Abstract: 
Pomegranate peel extracts prepared in our laboratories from a waste of juice fruit processing were tested on bovine peripheral blood mononuclear cells to evaluate the effects on viability, oxidative stress and proliferation. The (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide) assay pointed out that the extracts were not cytotoxic at the tested concentrations (0.1, 1.0, and 10 mg/mL). A moderate protective effect against Reactive Oxygen Species production induced by hydrogen peroxide or lipopolysaccharide and a significant anti-proliferative activity against proliferation induced by concanavalin A were observed on cell lines treated with the extracts at 10 lg/mL. Based on these results, pomegranate peel extracts seem promising as feed supplement for dairy cattle, in particular around calving, when the animals are subjected to an increase of the metabolic activity, responsible for oxidative stress and diseases. However, in vivo studies are needed to investigate the stability of the extracts across the bovine gastrointestinal tract barrier.
URI: http://hdl.handle.net/2067/42817
ISSN: 2072-6643
DOI: 10.3390/nu11030548
Appears in Collections:A1. Articolo in rivista

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