Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/42807
DC FieldValueLanguage
dc.contributor.authorFanelli, Giuseppinait
dc.contributor.authorBelardo, Antonioit
dc.contributor.authorSavino, Roccoit
dc.contributor.authorRinalducci, Sarait
dc.contributor.authorZolla, Lelloit
dc.date.accessioned2021-02-13T22:48:51Z-
dc.date.available2021-02-13T22:48:51Z-
dc.date.issued2020it
dc.identifier.issn1582-1838it
dc.identifier.urihttp://hdl.handle.net/2067/42807-
dc.description.abstractMale hypogonadism is notoriously associated with altered lipid metabolism. In this study, we performed an untargeted mass spectrometry-based profiling of plasma lipids from twenty healthy and twenty hypogonadal men before and after testosterone replacement therapy (TRT) for 60 days. Results demonstrated that hypogonadism was associated with a significant increase in sphingomyelin (SM), whereas phosphatidylcholine (PC) was mainly cleaved by activated phospholipase-A2 into lysophosphatidylcholine (LPC). In hypogonadal patients, arachidonic acid (AA), also produced through the latter cleavage, was prevalently bio-transformed into leukotriene B4 (LTB4) and not into endoperoxides from which prostaglandins and thromboxanes are derived. Interestingly, upon testosterone treatment SM, PC and LPC returned to levels similar to controls. Also, AA was newly converted into prostaglandin-A2, thromboxane-A2 and 5(S)-hydroxyeicosatetraenoic acid (HETE), suggesting that testosterone probably plays a role in controlling hypogonadal alterations above reported.it
dc.language.isoengit
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleTestosterone replacement therapy in insulin-sensitive hypogonadal men restores phosphatidylcholine levels by regulation of arachidonic acid metabolismit
dc.typearticle*
dc.identifier.doi10.1111/jcmm.15392it
dc.identifier.pmid32491269it
dc.identifier.scopus2-s2.0-85085887447it
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.15392it
dc.relation.journalJOURNAL OF CELLULAR AND MOLECULAR MEDICINEit
dc.relation.firstpage8266it
dc.relation.lastpage8269it
dc.relation.volume24it
dc.relation.issue14it
dc.description.internationalnoit
dc.contributor.countryITAit
dc.type.refereeREF_1it
dc.type.miur262*
item.fulltextWith Fulltext-
item.openairetypearticle-
item.cerifentitytypePublications-
item.grantfulltextrestricted-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.journal.journalissn1582-1838-
crisitem.journal.anceE184185-
Appears in Collections:A1. Articolo in rivista
Files in This Item:
File Description SizeFormat
J Cell Mol Med 2020_hypogonadism.pdf459.74 kBAdobe PDFView/Open
Show simple item record

SCOPUSTM   
Citations 20

9
Last Week
0
Last month
0
checked on Mar 22, 2024

Page view(s)

112
Last Week
1
Last month
1
checked on Mar 27, 2024

Download(s)

20
checked on Mar 27, 2024

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons