Please use this identifier to cite or link to this item:
http://hdl.handle.net/2067/42754
DC Field | Value | Language |
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dc.contributor.author | Bizzarri, Bruno Mattia | it |
dc.contributor.author | Pieri, Cristina | it |
dc.contributor.author | Botta, Giorgia | it |
dc.contributor.author | Arabuli, Lili | it |
dc.contributor.author | Mosesso, Pasquale | it |
dc.contributor.author | Cinelli, Serena | it |
dc.contributor.author | Schinoppi, Angelo | it |
dc.contributor.author | Saladino, Raffele | it |
dc.date.accessioned | 2021-02-08T13:32:00Z | - |
dc.date.available | 2021-02-08T13:32:00Z | - |
dc.date.issued | 2015 | it |
dc.identifier.issn | 2046-2069 | it |
dc.identifier.uri | http://hdl.handle.net/2067/42754 | - |
dc.description.abstract | DOPA peptidomimetics with stable O-C and N-C covalent bonds between amino acid residues have been prepared by aromatic oxidative functionalization of tyrosine with 2-iodoxybenzoic acid (IBX). The reaction involves the Michael-like nucleophilic addition of different oxygen and nitrogen protected amino acids on a reactive DOPA quinone intermediate. Similar results were obtained in heterogeneous conditions using supported IBX-amide for more runs. Among the novel derivatives, compounds containing glycine residues showed a more pronounced antioxidant activity in the 2,2-diphenyl picrylhydrazyl (DPPH) radical scavenging cell free assay. Instead, valine derivatives showed the highest biological effect in L5178Y mouse lymphoma cells, by assessing the ability to reduce H<inf>2</inf>O<inf>2</inf> induced DNA breakage in the alkaline comet assay. | it |
dc.language.iso | eng | it |
dc.rights | CC0 1.0 Universal | * |
dc.rights.uri | http://creativecommons.org/publicdomain/zero/1.0/ | * |
dc.title | Synthesis and antioxidant activity of DOPA peptidomimetics by a novel IBX mediated aromatic oxidative functionalization | it |
dc.type | article | * |
dc.identifier.doi | 10.1039/c5ra09464j | it |
dc.identifier.scopus | 2-s2.0-84937138685 | it |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84937138685 | it |
dc.relation.journal | RSC ADVANCES | it |
dc.relation.firstpage | 60354 | it |
dc.relation.lastpage | 60364 | it |
dc.relation.volume | 5 | it |
dc.relation.issue | 74 | it |
dc.type.miur | 262 | * |
item.fulltext | With Fulltext | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | restricted | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.journal.journalissn | 2046-2069 | - |
crisitem.journal.ance | E206163 | - |
Appears in Collections: | A1. Articolo in rivista |
Files in This Item:
File | Description | Size | Format | Existing users please |
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Synthesis and antioxidant activity of DOPA RSC Adv., 2015, 5, 60354.pdf | 716.82 kB | Adobe PDF | Request a copy |
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