Please use this identifier to cite or link to this item:
http://hdl.handle.net/2067/42753
Title: | Laccase-catalyzed 1,4-dioxane-mediated synthesis of belladine n-oxides with anti-influenza a virus activity | Authors: | Zippilli, Claudio botta, lorenzo Bizzarri, Bruno Mattia Nencioni, Lucia De Angelis, Marta Protto, Virginia Giorgi, Gianluca Baratto, Maria Camilla Pogni, Rebecca Saladino, Raffaele |
Journal: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | Issue Date: | 2021 | Abstract: | Belladine N-oxides active against influenza A virus have been synthetized by a novel laccase-catalyzed 1,4-dioxane-mediated oxidation of aromatic and side-chain modified belladine derivatives. Electron paramagnetic resonance (EPR) analysis confirmed the role of 1,4-dioxane as a co-oxidant. The reaction was chemo-selective, showing a high functional-group compatibility. The novel belladine N-oxides were active against influenza A virus, involving the early stage of the virus replication life cycle. |
URI: | http://hdl.handle.net/2067/42753 | ISSN: | 1422-0067 | DOI: | 10.3390/ijms22031337 | Rights: | CC0 1.0 Universal |
Appears in Collections: | A1. Articolo in rivista |
Files in This Item:
File | Description | Size | Format | Existing users please |
---|---|---|---|---|
Laccase-Catalyzed 1,4-Dioxane-Mediated Synthesis of Belladine N-Oxides with Anti-Influenza A Virus Activity.pdf | 2.07 MB | Adobe PDF | Request a copy |
SCOPUSTM
Citations
10
4
Last Week
0
0
Last month
0
0
checked on Mar 24, 2024
Page view(s)
90
Last Week
0
0
Last month
1
1
checked on Mar 27, 2024
Download(s)
4
checked on Mar 27, 2024
Google ScholarTM
Check
Altmetric
This item is licensed under a Creative Commons License