Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/42623
DC FieldValueLanguage
dc.contributor.authorGori, Manueleit
dc.contributor.authorGiannitelli, Sara Mariait
dc.contributor.authorZancla, Andreait
dc.contributor.authorMozetic, Pamelait
dc.contributor.authorTrombetta, Marcellait
dc.contributor.authorMerendino, Nicolo'it
dc.contributor.authorRainer, Albertoit
dc.date.accessioned2021-01-28T11:43:14Z-
dc.date.available2021-01-28T11:43:14Z-
dc.date.issued2021it
dc.identifier.issn0006-3592it
dc.identifier.urihttp://hdl.handle.net/2067/42623-
dc.description.abstractOrgans-on-chip (OoCs) are catching on as a promising and valuable alternative to animal models, in line with the 3Rs initiative. OoCs enable the creation of three-dimensional (3D) tissue microenvironments with physiological and pathological relevance at unparalleled precision and complexity, offering new opportunities to model human diseases and to test the potential therapeutic effect of drugs, while overcoming the limited predictive accuracy of conventional 2D culture systems. Here, we present a liver-on-a-chip model to investigate the effects of two naturally occurring polyphenols, namely quercetin and hydroxytyrosol, on nonalcoholic fatty liver disease (NAFLD) using a high-content analysis readout methodology. NAFLD is currently the most common form of chronic liver disease; however, its complex pathogenesis is still far from being elucidated, and no definitive treatment has been established so far. In our experiments, we observed that both polyphenols seem to restrain the progression of the free fatty acid-induced hepatocellular steatosis, showing a cytoprotective effect due to their antioxidant and lipid-lowering properties. In conclusion, the findings of the present work could guide novel strategies to contrast the onset and progression of NAFLD.it
dc.format.mediumELETTRONICOit
dc.language.isoengit
dc.rightsCC0 1.0 Universal*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.titleQuercetin and hydroxytyrosol as modulators of hepatic steatosis: A NAFLD-on-a-chip studyit
dc.typearticle*
dc.identifier.doi10.1002/bit.27557it
dc.identifier.pmid32889748it
dc.identifier.scopus2-s2.0-85090997511it
dc.identifier.isi000570318900001it
dc.relation.journalBiotechnology and bioengineeringit
dc.relation.firstpage142-152it
dc.relation.lastpage152it
dc.relation.volume118it
dc.relation.issue1it
dc.contributor.countryITAit
dc.type.refereeREF_1it
dc.type.miur262*
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
item.grantfulltextrestricted-
item.openairetypearticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
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