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Title: | Vibrational Changes Induced by Electron Transfer in Surface Bound Azurin Metalloprotein Studied by Tip-Enhanced Raman Spectroscopy and Scanning Tunneling Microscopy | Authors: | Kradolfer, S. Lipiec, E. Baldacchini, C. Bizzarri, Anna Rita Cannistraro, Salvatore Zenobi, R. |
Journal: | ACS NANO | Issue Date: | 2017 | Abstract: | The copper protein azurin, due to the peculiar coupling of its optical and vibronic properties with electron transfer (ET) and its biorecognition capabilities, is a very promising candidate for bioelectronic, bio-optoelectronic and biosensor applications. However, a complete understanding of the fundamental processes relating azurin ET and its optical and vibronic characteristics with the charge transport mechanisms occurring in proteins bound to a conductive surface, the typical scenario for a biosensor or bioelectronic component, is still lacking. We studied azurin proteins bound to a gold electrode surface by scanning tunneling microscopy combined with tip-enhanced Raman spectroscopy (STM-TERS). Robust TER spectra were obtained, and the protein's vibronic response under optical excitation in resonance with its ligand-to-metal charge transfer band was found to be affected by the tunneling parameters, indicating a direct involvement of the active site vibrations in the electron transport process. © 2017 American Chemical Society. |
URI: | http://hdl.handle.net/2067/42513 | ISSN: | 1936-0851 | DOI: | 10.1021/acsnano.7b07768 | Rights: | Attribution-NonCommercial-NoDerivatives 4.0 International |
Appears in Collections: | A1. Articolo in rivista |
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ACSNano2017.pdf | published version | 4.25 MB | Adobe PDF | Request a copy |
ACSnano_accepted_VQR.pdf | accepted version | 1.51 MB | Adobe PDF | View/Open |
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