Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/2067/42476
Titolo: | The Cockayne syndrome group A and B proteins are part of a ubiquitin-proteasome degradation complex regulating cell division | Autori: | Paccosi, Elena Costanzo, Federico Costantino, Michele Balzerano, Alessio Monteonofrio, Laura Soddu, Silvia Prantera, Giorgio Brancorsini, Stefano Egly, Jean-Marc Proietti De Santis, Luca |
Rivista: | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | Data pubblicazione: | 2020 | Abstract: | Cytokinesis is monitored by a molecular machinery that promotes the degradation of the intercellular bridge, a transient protein structure connecting the two daughter cells. Here, we found that CSA and CSB, primarily defined as DNA repair factors, are located at the midbody, a transient structure in the middle of the intercellular bridge, where they recruit CUL4 and MDM2 ubiquitin ligases and the proteasome. As a part of this molecular machinery, CSA and CSB contribute to the ubiquitination and the degradation of proteins such as PRC1, the Protein Regulator of Cytokinesis, to ensure the correct separation of the two daughter cells. Defects in CSA or CSB result in perturbation of the abscission leading to the formation of long intercellular bridges and multinucleated cells, which might explain part of the Cockayne syndrome phenotypes. Our results enlighten the role played by CSA and CSB as part of a ubiquitin/proteasome degradation process involved in transcription, DNA repair, and cell division. |
URI: | http://hdl.handle.net/2067/42476 | ISSN: | 0027-8424 | DOI: | 10.1073/pnas.2006543117 |
È visualizzato nelle collezioni: | A1. Articolo in rivista |
File in questo documento:
File | Descrizione | Dimensioni | Formato | Existing users please |
---|---|---|---|---|
PNAS paper recently published.pdf | 2.43 MB | Adobe PDF | Richiedi una copia |
SCOPUSTM
Citations
10
16
Last Week
0
0
Last month
1
1
controllato il 24-mar-2024
Page view(s)
93
Last Week
1
1
Last month
3
3
controllato il 27-mar-2024
Download(s)
5
controllato il 27-mar-2024
Google ScholarTM
Check
Altmetric
Tutti i documenti nella community "Unitus Open Access" sono pubblicati ad accesso aperto.
Tutti i documenti nella community Prodotti della Ricerca" sono ad accesso riservato salvo diversa indicazione per alcuni documenti specifici