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http://hdl.handle.net/2067/34272
Title: | Hydroxytyrosol-derived compounds: a basis for the creation of new pharmacological agents for cancer prevention and therapy | Authors: | Bernini, Roberta Gilardini Montani Ms Merendino, Nicolo' Romani, A. Velotti, Francesca Romana |
Journal: | JOURNAL OF MEDICINAL CHEMISTRY | Issue Date: | 2015 | Abstract: | Hydroxytyrosol [2-(3,4-dihydroxyphenyl)ethanol, HTyr] is a phenolic compound found in olive leaves and fruits and extra-virgin olive oil, which has well-known strong antioxidant and radical-scavenging properties. Recently, it has received particular attention for its antiproliferative and apoptotic activities and its anti-inflammatory properties. During the past few years, more efforts have been focused on synthesizing HTyr-derived compounds with enhanced biological activities for their potential use in different chronic degenerative diseases. In this paper, we report a dissertation on the current knowledge of selected synthetic HTyr derivatives and analogues and their potential use in cancer prevention and therapy, which are related to their antioxidant, antiproliferative/apoptotic, and anti-inflammatory properties. On the basis of the perspective of using HTyr-derived compounds as anticancer agents, we have taken into account only studies that were performed in experimental cell-based models. |
URI: | http://hdl.handle.net/2067/34272 | ISSN: | 0022-2623 | DOI: | 10.1021/acs.jmedchem.5b00669 |
Appears in Collections: | A1. Articolo in rivista |
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JMC 2015_submitted.pdf | 999.75 kB | Adobe PDF | View/Open |
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