Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/30640
DC FieldValueLanguage
dc.contributor.authorMiccoli, Andreait
dc.contributor.authorGioacchini Giorgiait
dc.contributor.authorMaradonna Francescait
dc.contributor.authorBenato, F.it
dc.contributor.authorSkobo Tatjanait
dc.contributor.authorCarnevali Olianait
dc.date.accessioned2020-10-20T22:45:25Z-
dc.date.available2020-10-20T22:45:25Z-
dc.date.issued2015it
dc.identifier.issn10158987it
dc.identifier.urihttp://hdl.handle.net/2067/30640-
dc.description.abstractProbiotic strains have been recognized to exert important roles in many biological systems, including immune response, growth, development and reproduction. However, to date, no studies have focused either on the relation among probiotics and maternal factors or on probiotics' ability to qualitatively and/or quantitatively modulate maternal transcripts. Methods: In this study, the effects of Lactobacillusrhamnosus administered to parental fish on the control of maternal factors involved in autophagic, apoptotic and dorsalizing processes during zebrafish embryo development were assessed through q-PCRs, WMISH and TUNEL assay. Results: The results we obtained show that probiotic induced significant changes in both maternal and zygotic mRNA levels involved in embryo development. The maternal autophagy-regulating genes herein investigated -ambra1a, ambra1b, beclin, lc3-, as well as those involved in the apoptotic process -caspase3, bcl2, bax- were modulated in disfavor and favor of the treated group, respectively. Also, the key transcripts ruling the dorsalizing process -goosecoid and chordin- were subject to a significant regulation of their gene expression. Conclusion: The results we acquired demonstrated that parentally administered Lactobacillusrhamnosus is able to modulate important physiological processes involved in zebrafish embryo development.it
dc.format.mediumELETTRONICOit
dc.language.isoengit
dc.titleBeneficial Bacteria Affect Danio rerio Development by the Modulation of Maternal Factors Involved in Autophagic, Apoptotic and Dorsalizing Processesit
dc.typearticleen
dc.identifier.doi10.1159/000373983it
dc.identifier.pmid25833742it
dc.identifier.scopus2-s2.0-84926143575it
dc.identifier.isi000353713900004it
dc.relation.issn10158987en
dc.relation.journalCELLULAR PHYSIOLOGY AND BIOCHEMISTRYit
dc.relation.firstpage1706it
dc.relation.lastpage1718it
dc.relation.numberofpages13it
dc.relation.conferencenameCELLULAR PHYSIOLOGY AND BIOCHEMISTRYen
dc.relation.volume35it
dc.relation.issue35it
dc.description.numberofauthors6it
dc.description.internationalnoit
dc.contributor.countryITAit
dc.type.miur262en
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
item.grantfulltextrestricted-
item.openairetypearticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.journal.journalissn1015-8987-
crisitem.journal.anceE034035-
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